Abstract 1491: Transcriptional heterogeneity identifies functional states of tumor-initiating cell differentiation in human colorectal cancer
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DOI: 10.1158/1538-7445.am2020-1491
Abstract: Tumor progression in colorectal cancer (CRC) is driven by a subpopulation of cells with tumor-initiating cell (TIC) activity. In the past, bulk experiments provided strong evidence for functional heterogeneity of the CRC TIC compartment with… read more here.
Keywords: functional states; cell differentiation; crc; cancer ... See more keywords
Investigating Emotions as Functional States Distinct From Feelings
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DOI: 10.1177/1754073918765662
Abstract: We defend a functionalist approach to emotion that begins by focusing on emotions as central states with causal connections to behavior and to other cognitive states. The approach brackets the conscious experience of emotion, lists… read more here.
Keywords: functional states; distinct feelings; emotions functional; states distinct ... See more keywords
Catching Nucleosome by Its Decorated Tails Determines Its Functional States
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DOI: 10.3389/fgene.2022.903923
Abstract: The fundamental packaging unit of chromatin, i.e., nucleosome, consists of ∼147 bp of DNA wrapped around a histone octamer composed of the core histones, H2A, H2B, H3, and H4, in two copies each. DNA packaged… read more here.
Keywords: decorated tails; nucleosome decorated; determines functional; catching nucleosome ... See more keywords
Conformational Flexibility and Local Frustration in the Functional States of the SARS-CoV-2 Spike B.1.1.7 and B.1.351 Variants: Mutation-Induced Allosteric Modulation Mechanism of Functional Dynamics and Protein Stability
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DOI: 10.3390/ijms23031646
Abstract: Structural and functional studies of the SARS-CoV-2 spike proteins have recently determined distinct functional states of the B.1.1.7 and B.1.351 spike variants, providing a molecular framework for understanding the mechanisms that link the effect of… read more here.
Keywords: frustration; mutation induced; sars cov; cov spike ... See more keywords