Inference of Developmental Hierarchy and Functional States of Exhausted T Cells from Epigenetic Profiles with Deep Learning
Sign Up to like & getrecommendations! Published in 2024 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.4c00261
Abstract: Exhausted T cells are a key component of immune cells that play a crucial role in the immune response against cancer and influence the efficacy of immunotherapy. Accurate assessment and measurement of T-cell exhaustion (TEX)… read more here.
Keywords: exhausted cells; cancer; hierarchy functional; states exhausted ... See more keywords
Abstract 1491: Transcriptional heterogeneity identifies functional states of tumor-initiating cell differentiation in human colorectal cancer
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Research"
DOI: 10.1158/1538-7445.am2020-1491
Abstract: Tumor progression in colorectal cancer (CRC) is driven by a subpopulation of cells with tumor-initiating cell (TIC) activity. In the past, bulk experiments provided strong evidence for functional heterogeneity of the CRC TIC compartment with… read more here.
Keywords: functional states; cell differentiation; crc; cancer ... See more keywords
Investigating Emotions as Functional States Distinct From Feelings
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DOI: 10.1177/1754073918765662
Abstract: We defend a functionalist approach to emotion that begins by focusing on emotions as central states with causal connections to behavior and to other cognitive states. The approach brackets the conscious experience of emotion, lists… read more here.
Keywords: functional states; distinct feelings; emotions functional; states distinct ... See more keywords
Bacillus drives functional states in synthetic plant root bacterial communities
Sign Up to like & getrecommendations! Published in 2025 at "Genome Biology"
DOI: 10.1186/s13059-025-03739-8
Abstract: Plant roots release root exudates to attract microbes that form root communities, which in turn promote plant health and growth. Root community assembly arises from millions of interactions between microbes and the plant, leading to… read more here.
Keywords: plant; root; root communities; drives functional ... See more keywords
Cellular morphodynamics as quantifiers for functional states of resident tissue macrophages in vivo
Sign Up to like & getrecommendations! Published in 2025 at "PLOS Computational Biology"
DOI: 10.1371/journal.pcbi.1011859
Abstract: Resident tissue macrophages (RTMs) are essential for tissue homeostasis. Their diverse functions, from monitoring interstitial fluids to clearing cellular debris, are accompanied by characteristic morphological changes that reflect their functional status. While current knowledge of… read more here.
Keywords: tissue macrophages; resident tissue; macrophages vivo; cell ... See more keywords
Catching Nucleosome by Its Decorated Tails Determines Its Functional States
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.903923
Abstract: The fundamental packaging unit of chromatin, i.e., nucleosome, consists of ∼147 bp of DNA wrapped around a histone octamer composed of the core histones, H2A, H2B, H3, and H4, in two copies each. DNA packaged… read more here.
Keywords: decorated tails; nucleosome decorated; determines functional; catching nucleosome ... See more keywords
SDA: a data-driven algorithm that detects functional states applied to the EEG of Guhyasamaja meditation
Sign Up to like & getrecommendations! Published in 2024 at "Frontiers in Neuroinformatics"
DOI: 10.3389/fninf.2023.1301718
Abstract: The study presents a novel approach designed to detect time-continuous states in time-series data, called the State-Detecting Algorithm (SDA). The SDA operates on unlabeled data and detects optimal change-points among intrinsic functional states in time-series… read more here.
Keywords: guhyasamaja meditation; data driven; states applied; functional states ... See more keywords
Conformational Flexibility and Local Frustration in the Functional States of the SARS-CoV-2 Spike B.1.1.7 and B.1.351 Variants: Mutation-Induced Allosteric Modulation Mechanism of Functional Dynamics and Protein Stability
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031646
Abstract: Structural and functional studies of the SARS-CoV-2 spike proteins have recently determined distinct functional states of the B.1.1.7 and B.1.351 spike variants, providing a molecular framework for understanding the mechanisms that link the effect of… read more here.
Keywords: frustration; mutation induced; sars cov; cov spike ... See more keywords