Functional Tolerance to Cysteine Mutations in Human α7 Nicotinic Acetylcholine Receptors.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.9b00647
Abstract: The α7 nicotinic acetylcholine receptor (α7 nAChR) is involved in various intracellular signaling pathways that mediate addiction, chronic pain, and other diseases, but its intracellular domain structures remain undetermined. The presence of seventeen native cysteines… read more here.
Keywords: cysteine; cysteine mutations; nicotinic acetylcholine; tolerance cysteine ... See more keywords
Apremilast Alters Behavioral Responses to Ethanol in Mice: II. Increased Sedation, Intoxication, and Reduced Acute Functional Tolerance
Sign Up to like & getrecommendations! Published in 2018 at "Alcoholism: Clinical and Experimental Research"
DOI: 10.1111/acer.13615
Abstract: BACKGROUND In our companion paper, we reported that the phosphodiesterase type 4 inhibitor apremilast reduced ethanol (EtOH) intake and preference in different drinking models in male and female C57BL/6J mice. In this study, we measured… read more here.
Keywords: apremilast; etoh induced; etoh; functional tolerance ... See more keywords