Alkyne‐ and azide‐functionalised cyclophellitol derivatives for selective glucuronidase targeting
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DOI: 10.1002/ejoc.202401076
Abstract: Heparanase is an endo‐acting β‐glucuronidase and the only known enzyme responsible for the regulation of heparan sulfate structures in the extracellular matrix. The enzyme is found to be significantly upregulated in aggressive cancer types, aiding… read more here.
Keywords: functionalised cyclophellitol; cyclophellitol derivatives; glucuronidase; derivatives selective ... See more keywords