Synthesis of functionalised isochromans: epoxides as aldehyde surrogates in hexafluoroisopropanol
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DOI: 10.1039/d2sc06692k
Abstract: The oxa-Pictet–Spengler reaction is arguably the most straightforward and modular way to construct the privileged isochroman motif, but its scope is largely limited to benzaldehyde derivatives and to electron-rich β-phenylethanols that lack substitution along the… read more here.
Keywords: synthesis functionalised; functionalised isochromans; epoxides aldehyde; synthesis ... See more keywords