Diverse meta-C–H Functionalization of Amides
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DOI: 10.1021/acscatal.0c01306
Abstract: Overriding the preference for favorable proximal metalation by ortho-directing amide group, a pyrimidine-based directing group (DG) has been demonstrated for diverse remote meta-C–H functionalizati... read more here.
Keywords: meta functionalization; diverse meta; functionalization amides;
Unified Approach to the Chemoselective α-Functionalization of Amides with Heteroatom Nucleophiles
Sign Up to like & getrecommendations! Published in 2019 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.9b06956
Abstract: Functionalization at the α-position of carbonyl compounds has classically relied on enolate chemistry. As a result, the generation of a new C–X bond, where X is more electronegative than carbon requires an oxidation event. Herein… read more here.
Keywords: amides heteroatom; approach chemoselective; functionalization amides; chemoselective functionalization ... See more keywords
Facile preparation of pyrimidinediones and thioacrylamides via reductive functionalization of amides.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc04170e
Abstract: The development of an efficient protocol for the reductive functionalization of amides into pyrimidinediones and amino-substituted thioacrylamides is presented. Enamines are generated in a highly chemoselective amide hydrosilylation reaction catalyzed by molybdenum hexacarbonyl in combination… read more here.
Keywords: functionalization amides; preparation pyrimidinediones; reductive functionalization; facile preparation ... See more keywords
Nitrogen-directed unactivated γ-C(sp3)–H functionalization of amides toward 7-membered lactones via photoredox catalysis
Sign Up to like & getrecommendations! Published in 2024 at "Organic Chemistry Frontiers"
DOI: 10.1039/d4qo00564c
Abstract: Lactone motifs are prevalent in both naturally and synthetically bioactive molecules. We report herein a photoredox-catalyzed formal [5 + 2] annulation of O-acylhydroxamide derivatives with 1,3-dienes/1,3-enynes for rapid synthesis of... read more here.
Keywords: functionalization amides; sp3 functionalization; amides toward; nitrogen directed ... See more keywords