C-H Functionalization of Peptides via Cyclic Aminal Intermediates.
Sign Up to like & getrecommendations! Published in 2021 at "Organic letters"
DOI: 10.1021/acs.orglett.1c02041
Abstract: Protected dipeptides can be converted into cyclic ketoaminals, which can be subjected to palladium-catalyzed regioselective C-H functionalization. The best results are obtained using the 2-(methylthio)aniline (MTA) directing group, which is superior to the commonly used… read more here.
Keywords: peptides via; via cyclic; aminal intermediates; cyclic aminal ... See more keywords
Umpolung strategies for the functionalization of peptides and proteins
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DOI: 10.1039/d1sc06133j
Abstract: Umpolung strategies, defined as synthetic approaches which reverse commonly accepted reactivity patterns, are broadly recognized as enabling tools for small molecule synthesis and catalysis. However, methods which exploit this logic for peptide and protein functionalizations… read more here.
Keywords: umpolung strategies; functionalization peptides; chemistry; strategies functionalization ... See more keywords