New methodology for one-pot С–H functionalization of pyridines without the use of transition metal catalysts (microreview)
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DOI: 10.1007/s10593-018-2358-z
Abstract: This microreview is devoted to one-pot methodology for C–H functionalization of pyridines, which involve their preliminary N-activation through the formation of pyridinium salts (or coordination of electrophilic species with the nitrogen atom), followed by С-functionalization… read more here.
Keywords: functionalization pyridines; methodology; new methodology; one pot ... See more keywords
Photochemical Organocatalytic Functionalization of Pyridines via Pyridinyl Radicals
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DOI: 10.1021/jacs.2c12466
Abstract: We report a photochemical method for the functionalization of pyridines with radicals derived from allylic C–H bonds. Overall, two substrates undergo C–H functionalization to form a new C(sp2)–C(sp3) bond. The chemistry harnesses the unique reactivity… read more here.
Keywords: functionalization pyridines; functionalization; chemistry; photochemical organocatalytic ... See more keywords
Radical and ionic meta-C–H functionalization of pyridines, quinolines, and isoquinolines
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DOI: 10.1126/science.ade6029
Abstract: Carbon-hydrogen (C−H) functionalization of pyridines is a powerful tool for the rapid construction and derivatization of many agrochemicals, pharmaceuticals, and materials. Because of the inherent electronic properties of pyridines, selective meta-C−H functionalization is challenging. Here,… read more here.
Keywords: functionalization pyridines; meta functionalization; functionalization; meta ... See more keywords