Synthesis of Functionalized Cyclooctynes as Building Blocks for Non‐covalent Surface‐Orthogonal Chemistry
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Organic Chemistry"
DOI: 10.1002/ejoc.202500124
Abstract: Cyclooctynes substituted with functional groups capable for hydrogen bonding (amide, imide, carboxylic acid) have been synthesized. The 8‐membered ring was derived from cyclooctadiene, by Beckmann rearrangement or by ring‐closing metathesis. The transannular instability of a… read more here.
Keywords: chemistry; functionalized cyclooctynes; surface orthogonal; synthesis functionalized ... See more keywords
From Bio- to Surface-Orthogonal Chemistry: Synthetic Routes to Functionalized Cyclooctynes
Sign Up to like & getrecommendations! Published in 2025 at "Synlett"
DOI: 10.1055/a-2608-1808
Abstract: In this article, syntheses of functionalized cyclooctynes for bio- and surface-orthogonal applications are described and compared. Points of interest include their chemoselective reactivity in cycloadditions and their compatibility with transannular side reactions. Applications of cyclooctynes… read more here.
Keywords: bio surface; chemistry; functionalized cyclooctynes; cyclooctynes bio ... See more keywords