Tandem Reaction of Azide with Isonitrile and TMSCnFm(H): Access to N-Functionalized C-Fluoroalkyl Amidine.
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DOI: 10.1021/acs.orglett.3c00125
Abstract: N-Functionalized C-fluoroalkyl amidines are attracting great attention due to their potential in pharmaceuticals. Herein, we report a Pd-catalyzed tandem reaction of azide with isonitrile and fluoroalkylsilane via a carbodiimide intermediate, providing facile access to N-functionalized… read more here.
Keywords: reaction azide; functionalized fluoroalkyl; access functionalized; azide isonitrile ... See more keywords