Cu/base co-catalyzed [3+3] cycloaddition for the synthesis of highly functionalized 4-fluoropyridines.
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DOI: 10.1039/d1cc05412k
Abstract: An efficient, straightforward and general method for the de novo synthesis of highly functionalized 4-fluoropyridines was developed via a cooperative copper- and base-catalyzed [3+3] cycloaddition of active methylene isocyanides with difluorocyclopropenes. The resulting 4-fluoropyridines can… read more here.
Keywords: functionalized fluoropyridines; base catalyzed; catalyzed cycloaddition; synthesis highly ... See more keywords