Synthesis of Functionalized δ‐Hydroxy‐β‐keto Esters and Evaluation of Their Anti‐inflammatory Properties
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DOI: 10.1002/cbic.202200073
Abstract: δ‐Hydroxy‐β‐keto esters and δ,β‐dihydroxy esters are characteristic structural motifs of statin‐type natural products and drug candidates. Here, we describe the synthesis of functionalized δ‐hydroxy‐β‐keto esters in good yields and excellent enantioselectivities using Chan's diene and… read more here.
Keywords: synthesis functionalized; functionalized hydroxy; hydroxy keto; keto esters ... See more keywords
Direct Transition‐Metal‐Free Enantioselective Hydroxylation: Expeditious Access to 3‐Functionalized 3‐Hydroxy‐2‐oxindoles
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DOI: 10.1002/ejoc.202301313
Abstract: Inspired by the ubiquitous prevalence of 3‐hydroxy‐oxindoles in natural products and pharmaceuticals, we herein disclose a direct and practical transition‐metal‐free asymmetric hydroxylation using commercially available Davis enantiopure oxaziridines as efficient oxidants, expeditiously affording an array… read more here.
Keywords: metal free; transition metal; functionalized hydroxy; hydroxy oxindoles ... See more keywords