2D‐2D Nanocomposite of MoS2‐Graphitic Carbon Nitride as Multifunctional Catalyst for Sustainable Synthesis of C3‐Functionalized Indoles
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DOI: 10.1002/cctc.201800369
Abstract: A nanocomposite of two‐dimensional MoS2 supported on graphitic C3N4 nanosheets has been prepared by a facile ultrasonication method followed by demonstrating its ability to catalyze the synthesis of several indole derivatives. The as‐prepared nanocomposite catalyst… read more here.
Keywords: functionalized indoles; synthesis functionalized; nanocomposite mos2; catalyst ... See more keywords
Ni-Catalyzed Reductive Coupling of Alkynes and Amides to Access Multi-Functionalized Indoles.
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DOI: 10.1021/acs.orglett.1c03971
Abstract: A nickel-catalyzed reductive coupling of alkynes and amides, followed by base-free transmetalation, proceeded selectively in the presence of an uncommon bidentate primary aminophosphine ligand to access highly functionalized indoles comprising biologically important trifluoromethyl groups and… read more here.
Keywords: functionalized indoles; alkynes amides; reductive coupling; catalyzed reductive ... See more keywords
Palladium-Catalyzed Synthesis of Functionalized Indoles by Acylation/Allylation of 2-Alkynylanilines with Three-Membered Rings.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00246
Abstract: Palladium-catalyzed synthesis of 3-acyl and -allyl indoles has been realized by merging nucleophilic cyclization of ortho-alkynylanilines with ring opening of three-membered rings such as cyclopropenones and gem-difluorinated cyclopropanes. These functionalized indoles were obtained in moderate… read more here.
Keywords: functionalized indoles; palladium catalyzed; three membered; membered rings ... See more keywords
Synthesis of C7-Functionalized Indoles through an Aromaticity Destruction-Reconstruction Process.
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DOI: 10.1021/acs.orglett.2c00733
Abstract: A process for the synthesis of C7-functionalized indoles using para-substituted 2-alkynylanilines as starting materials was reported. The process involves a dearomatization, an 1,2-addition by organic lithium or Grignard reagents, an aromatization-driven allylic rearrangement, and a… read more here.
Keywords: synthesis functionalized; functionalized indoles; indoles aromaticity; process synthesis ... See more keywords
Modular Divergent Synthesis of Functionalized Indoles via TFA-Promoted Amino-Claisen Rearrangement at Room Temperature.
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DOI: 10.1021/acs.orglett.3c00764
Abstract: A conceptually novel approach for the modular and divergent synthesis of highly functionalized indoles via trifluoroacetic acid-promoted amino-Claisen rearrangement is reported. This metal-free protocol could be performed at room temperature with wide functional group tolerance.… read more here.
Keywords: amino claisen; functionalized indoles; divergent synthesis; indoles via ... See more keywords
Direct Access to Functionalized Indoles via Single Electron Oxidation Induced Coupling of Diarylamines with 1,3-Dicarbonyl Compounds.
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DOI: 10.1021/acs.orglett.9b02349
Abstract: Under aerobic copper catalysis, an unprecedented direct synthesis of functionalized indoles via single electron oxidation induced coupling of diarylamines with 1,3-dicarbonyl compounds is presented. The protocol proceeds with good functional group and substrate compatibility, the… read more here.
Keywords: functionalized indoles; single electron; oxidation induced; indoles via ... See more keywords