Electrochemical Synthesis of β-Functionalized Ketones via Ring-Opening of Cycloalkanols.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c01649
Abstract: The electrochemical deconstructive functionalization of cycloalkanols with nucleophiles has been studied, which allows functionalization to occur exclusively at the β-position of ketones. The substrate scope includes a wide range of cycloalkanols as well as diverse… read more here.
Keywords: electrochemical synthesis; synthesis functionalized; ketones via; functionalized ketones ... See more keywords
Four-Component Radical Dual Difunctionalization (RDD) of Two Different Alkenes with Aldehydes and tert-Butyl Hydroperoxide (TBHP): An Easy Access to β,δ-Functionalized Ketones.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b02264
Abstract: A convenient Fe-catalyzed four-component radical dual difunctionalization and ordered assembly of two alkenes with aromatic/aliphatic aldehydes and TBHP to provide chain elongated β,δ-functionalized ketones via a one-pot procedure has been developed. Aldehydes were homolytically cleavaged… read more here.
Keywords: four component; radical dual; dual difunctionalization; functionalized ketones ... See more keywords
Organocatalyzed Kinetic Resolution of α-Functionalized Ketones: The Malonate Unit Leads the Way
Sign Up to like & getrecommendations! Published in 2020 at "ACS Catalysis"
DOI: 10.1021/acscatal.9b05608
Abstract: Developing a catalytic kinetic resolution (KR) protocol affording enantioenriched α-functionalized ketones with broad substrate scope and high efficiency has been a longstanding challenge. Here, we... read more here.
Keywords: ketones malonate; resolution functionalized; kinetic resolution; organocatalyzed kinetic ... See more keywords
Access to β-Alkylated γ-Functionalized Ketones via Conjugate Additions to Arylideneisoxazol-5-ones and Mo(CO)6-Mediated Reductive Cascade Reactions
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.1c07081
Abstract: 1,4-Conjugate addition of ((chloromethyl)sulfonyl)benzenes to arylideneisoxazol-5-ones, followed by one-pot, N-selective trapping in the presence of electrophiles, was investigated. This strategy led to the synthesis of new, stable N-protected isoxazol-5-ones in good yields and high diastereolectivity.… read more here.
Keywords: cascade; alkylated functionalized; arylideneisoxazol ones; access alkylated ... See more keywords