HFIP-Mediated Spiro-annulation of Bicyclo[1.1.0]butanes with α-Halo Hydroxamates: Access to Functionalized Spirocyclobutenes.
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DOI: 10.1021/acs.orglett.5c02493
Abstract: Bicyclo[1.1.0]butanes (BCBs) are activated using photocatalysts, Lewis and Brønsted acids, transition metal catalysts, and more recently hexafluoroisopropanol (HFIP). On the other hand, α-halo hydroxamates are known to generate reactive azaoxyallyl cations in the presence of… read more here.
Keywords: spiro annulation; functionalized spirocyclobutenes; halo hydroxamates; bicyclo butanes ... See more keywords