Fragment Libraries Designed to Be Functionally Diverse Recover Protein Binding Information More Efficiently Than Standard Structurally Diverse Libraries
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medicinal Chemistry"
DOI: 10.1021/acs.jmedchem.2c01004
Abstract: Current fragment-based drug design relies on the efficient exploration of chemical space though the use of structurally diverse libraries of small fragments. However, structurally dissimilar compounds can exploit the same interactions on a target, and… read more here.
Keywords: information; diverse libraries; structurally diverse; functionally diverse ... See more keywords
OSCAR: an extensive repository of chemically and functionally diverse organocatalysts
Sign Up to like & getrecommendations! Published in 2022 at "Chemical Science"
DOI: 10.1039/d2sc04251g
Abstract: The automated construction of datasets has become increasingly relevant in computational chemistry. While transition-metal catalysis has greatly benefitted from bottom-up or top-down strategies for the curation of organometallic complexes libraries, the field of organocatalysis is… read more here.
Keywords: extensive repository; chemically functionally; repository; repository chemically ... See more keywords
Evolutionary and molecular foundations of multiple contemporary functions of the nitroreductase superfamily
Sign Up to like & getrecommendations! Published in 2017 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1706849114
Abstract: Significance Functionally diverse enzyme superfamilies are sets of homologs that conserve a structural fold and mechanistic details but perform various distinct chemical reactions. What are the evolutionary routes by which ancestral proteins diverge to produce… read more here.
Keywords: molecular foundations; flavin; enzyme superfamilies; foundations multiple ... See more keywords
Alternative 3′ UTRs direct localization of functionally diverse protein isoforms in neuronal compartments
Sign Up to like & getrecommendations! Published in 2019 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky1270
Abstract: The proper subcellular localization of RNAs and local translational regulation is crucial in highly compartmentalized cells, such as neurons. RNA localization is mediated by specific cis-regulatory elements usually found in mRNA 3'UTRs. Therefore, processes that… read more here.
Keywords: protein isoforms; alternative utrs; localization functionally; functionally diverse ... See more keywords
How functionally diverse are fish in the deep? A comparison of fish communities in deep and shallow‐water systems
Sign Up to like & getrecommendations! Published in 2021 at "Diversity and Distributions"
DOI: 10.1111/ddi.13268
Abstract: Functional diversity metrics inform how species’ traits relate to ecosystem functions, useful for quantifying how exploitation and disturbance impact ecosystems. We compare the functional diversity of entire fish communities in a shallow‐water region with a… read more here.
Keywords: fish deep; shallow water; fish communities; diverse fish ... See more keywords
Rewilding Europe's large grazer community: how functionally diverse are the diets of European bison, cattle, and horses?
Sign Up to like & getrecommendations! Published in 2018 at "Restoration Ecology"
DOI: 10.1111/rec.12661
Abstract: Trophic rewilding is the introduction of species to restore top–down trophic interactions and associated trophic cascades to promote self-regulating biodiverse ecosystems. A core example of trophic rewilding is the restoration of large mammalian grazer communities… read more here.
Keywords: bison; diverse diets; cattle horses; european bison ... See more keywords