Conversion of microbial rhodopsins: insights into functionally essential elements and rational protein engineering
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Reviews"
DOI: 10.1007/s12551-017-0335-x
Abstract: Technological progress has enabled the successful application of functional conversion to a variety of biological molecules, such as nucleotides and proteins. Such studies have revealed the functionally essential elements of these engineered molecules, which are… read more here.
Keywords: functional conversion; conversion; functionally essential; conversion microbial ... See more keywords
Unconventional Split Aptamers Cleaved at Functionally Essential Sites Preserve Biorecognition Capability.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.9b04115
Abstract: Split aptamers (SPAs) are a pair of oligonucleotide fragments generated by cleaving a long parent aptamer. SPAs have many compelling advantages over the parent aptamer such as sandwich target binding, optimized concise structure, and low… read more here.
Keywords: spas; functionally essential; biorecognition capability; split aptamers ... See more keywords
Delineation of functionally essential protein regions for 242 neurodevelopmental genes
Sign Up to like & getrecommendations! Published in 2022 at "Brain"
DOI: 10.1093/brain/awac381
Abstract: Abstract Neurodevelopmental disorders (NDDs), including severe paediatric epilepsy, autism and intellectual disabilities are heterogeneous conditions in which clinical genetic testing can often identify a pathogenic variant. For many of them, genetic therapies will be tested… read more here.
Keywords: essential protein; essential3d sites; delineation functionally; functionally essential ... See more keywords