FishShapes v1: Functionally relevant measurements of teleost shape and size on three dimensions
Sign Up to like & getrecommendations! Published in 2022 at "Ecology"
DOI: 10.1002/ecy.3829
Abstract: Abstract Teleost fishes account for 96% of all fish species and exhibit a spectacular variety of body forms. Teleost lineages range from deep bodied to elongate (e.g., eels, needlefish), laterally compressed (e.g., ribbonfish) to globular… read more here.
Keywords: functionally relevant; relevant measurements; teleost; shape ... See more keywords
IL-17A is functionally relevant and a potential therapeutic target in bullous pemphigoid.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2018.09.003
Abstract: IL-17A has been identified as key regulatory molecule in several autoimmune and chronic inflammatory diseases followed by the successful use of anti-IL-17 therapy, e.g. in ankylosing spondylitis and psoriasis. Bullous pemphigoid (BP) is the most… read more here.
Keywords: 17a functionally; relevant potential; bullous pemphigoid; functionally relevant ... See more keywords
Altered Domain Structure of the Prion Protein Caused by Cu2+ Binding and Functionally Relevant Mutations: Analysis by Cross-Linking, MS/MS, and NMR.
Sign Up to like & getrecommendations! Published in 2019 at "Structure"
DOI: 10.1016/j.str.2019.03.008
Abstract: The cellular isoform of the prion protein (PrPC) serves as precursor to the infectious isoform (PrPSc), and as a cell-surface receptor, which binds misfolded protein oligomers as well as physiological ligands such as Cu2+ ions.… read more here.
Keywords: protein; relevant mutations; prion protein; functionally relevant ... See more keywords
NMR Reveals Functionally Relevant Thermally Induced Structural Changes within the Native Ensemble of G-CSF
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.2c00398
Abstract: Structure–function relationships in proteins refer to a trade-off between stability and bioactivity, molded by evolution of the molecule. Identifying which protein amino acid residues jeopardize global or local stability for the benefit of bioactivity would… read more here.
Keywords: csf; reveals functionally; relevant thermally; functionally relevant ... See more keywords
Serum neurofilament light chain in functionally relevant coronary artery disease and adverse cardiovascular outcomes
Sign Up to like & getrecommendations! Published in 2023 at "Biomarkers"
DOI: 10.1080/1354750x.2023.2172211
Abstract: Abstract Background: Functionally relevant coronary artery disease (fCAD), causing symptoms of myocardial ischemia, can currently only be reliably detected with advanced cardiac imaging. Serum neurofilament light chain (sNfL) is a biomarker for neuro-axonal injury known… read more here.
Keywords: relevant coronary; snfl; functionally relevant; death ... See more keywords
Development and Validation of a Functionally-Relevant Comorbid Health Index in Adults Admitted to Inpatient Rehabilitation for Traumatic Brain Injury.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of neurotrauma"
DOI: 10.1089/neu.2021.0180
Abstract: Several studies have characterized comorbidities among individuals with traumatic brain injury (TBI); however, there are few validated TBI comorbidity indices. Widely-used indices (e.g., Elixhauser Comorbidity Index [ECI]) were developed in other patient populations and anchor… read more here.
Keywords: index; traumatic brain; validation; functionally relevant ... See more keywords
enrichMiR predicts functionally relevant microRNAs based on target collections
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac395
Abstract: Abstract MicroRNAs (miRNAs) are small non-coding RNAs that are among the main post-transcriptional regulators of gene expression. A number of data collections and prediction tools have gathered putative or confirmed targets of these regulators. It… read more here.
Keywords: target; enrichmir predicts; functionally relevant; predicts functionally ... See more keywords
Integrative genomics analysis highlights functionally relevant genes for equine behaviour.
Sign Up to like & getrecommendations! Published in 2023 at "Animal genetics"
DOI: 10.1111/age.13320
Abstract: Behavioural plasticity enables horses entering an exercise training programme to adapt with reduced stress. We characterised SNPs associated with behaviour in yearling Thoroughbred horses using genomics analyses for two phenotypes: (1) handler-assessed coping with early… read more here.
Keywords: genomics analysis; functionally relevant; relevant genes; analysis highlights ... See more keywords
Concurrent Mutations in Oncogenes Functionally Relevant.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-nd2020-013
Abstract: Although single hotspot mutations in oncogenes have been the focus of much research, the clinical relevance of oncogenes with multiple mutations-now shown to be common-has only recently come into the spotlight. read more here.
Keywords: oncogenes functionally; functionally relevant; concurrent mutations; mutations oncogenes ... See more keywords
Prospective Validation of a Biomarker-Based Rule Out Strategy for Functionally Relevant Coronary Artery Disease.
Sign Up to like & getrecommendations! Published in 2018 at "Clinical chemistry"
DOI: 10.1373/clinchem.2017.277210
Abstract: BACKGROUND This study aimed to prospectively advance a rule-out strategy for functionally significant coronary artery disease (CAD) by use of high-sensitivity cardiac troponin I (hs-cTnI) from bench to bedside, by application of a 3-step approach:… read more here.
Keywords: validation; cad; cohort; relevant cad ... See more keywords
Functionally relevant proteins in Plasmodium falciparum host cell invasion.
Sign Up to like & getrecommendations! Published in 2017 at "Immunotherapy"
DOI: 10.2217/imt-2016-0091
Abstract: A totally effective, antimalarial vaccine must involve sporozoite and merozoite proteins (or their fragments) to ensure complete parasite blocking during critical invasion stages. This Special Report examines proteins involved in critical biological functions for parasite… read more here.
Keywords: proteins plasmodium; invasion; plasmodium falciparum; falciparum host ... See more keywords