DeepFunc: A Deep Learning Framework for Accurate Prediction of Protein Functions from Protein Sequences and Interactions
Sign Up to like & getrecommendations! Published in 2019 at "PROTEOMICS"
DOI: 10.1002/pmic.201900019
Abstract: Annotation of protein functions plays an important role in understanding life at the molecular level. High‐throughput sequencing produces massive numbers of raw proteins sequences and only about 1% of them have been manually annotated with… read more here.
Keywords: protein; deep learning; learning framework; functions protein ... See more keywords
Towards descriptor of elementary functions for protein design.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in structural biology"
DOI: 10.1016/j.sbi.2019.06.010
Abstract: We review studies of the protein evolution that help to formulate rules for protein design. Acknowledging the fundamental importance of Dayhoff's provision on the emergence of functional proteins from short peptides, we discuss multiple evidences… read more here.
Keywords: elementary functions; protein design; towards descriptor; descriptor elementary ... See more keywords
Deciphering the Functions of Protein O-GlcNAcylation with Chemistry.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.6b01065
Abstract: O-GlcNAcylation is the modification of serine and threonine residues with β-N-acetylglucosamine (O-GlcNAc) on intracellular proteins. This dynamic modification is attached by O-GlcNAc transferase (OGT) and removed by O-GlcNAcase (OGA) and is a critical regulator of… read more here.
Keywords: deciphering functions; chemistry; glcnacylation; protein glcnacylation ... See more keywords
Pleiotropic anticoagulant functions of protein S, consequences for the clinical laboratory. Communication from the SSC of the ISTH
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15108
Abstract: Hereditary deficiencies of protein S (PS) increase the risk of thrombosis. However, assessing the plasma levels of PS is complicated by its manifold physiological interactions, while the large inter‐individual variability makes it problematic to establish… read more here.
Keywords: anticoagulant functions; communication; pleiotropic anticoagulant; clinical laboratory ... See more keywords
Multifaceted Functions of Protein Kinase D in Pathological Processes and Human Diseases
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DOI: 10.3390/biom11030483
Abstract: Protein kinase D (PKD) is a family of serine/threonine protein kinases operating in the signaling network of the second messenger diacylglycerol. The three family members, PKD1, PKD2, and PKD3, are activated by a variety of… read more here.
Keywords: human diseases; pathological processes; multifaceted functions; protein kinase ... See more keywords