Canonical and extra-telomeric functions of telomerase: Implications for healthy ageing conferred by endurance training.
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DOI: 10.1111/acel.13836
Abstract: Telomerase preserves genomic integrity by maintaining and protecting the telomeres. Seminal findings from 1985 revealed the canonical role of telomerase and motivated investigations into potential therapeutic strategies to combat one of the hallmarks of ageing-telomere… read more here.
Keywords: extra telomeric; telomerase; endurance training; canonical extra ... See more keywords
Many Functions of Telomerase Components: Certainties, Doubts, and Inconsistencies
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DOI: 10.3390/ijms232315189
Abstract: A growing number of studies have evidenced non-telomeric functions of “telomerase”. Almost all of them, however, investigated the non-canonical effects of the catalytic subunit TERT, and not the telomerase ribonucleoprotein holoenzyme. These functions mainly comprise… read more here.
Keywords: gene regulation; functions telomerase; many functions; certainties doubts ... See more keywords