Macrophage-derived exosomes in cancers: Biogenesis, functions and therapeutic applications.
Sign Up to like & getrecommendations! Published in 2020 at "Immunology letters"
DOI: 10.1016/j.imlet.2020.08.003
Abstract: Macrophages are fundamental to promote tumorigenesis, tumor development and metastasis, and chemotherapy resistance through modulating tumor microenvironment and cancer cells. Recently, increasing studies have shown that exosomes could play a crucial role in orchestrating the… read more here.
Keywords: functions therapeutic; cancers biogenesis; exosomes cancers; macrophage derived ... See more keywords
Molecular insights into the multifaceted functions and therapeutic targeting of high mobility group box 1 in metabolic diseases
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.17448
Abstract: HMGB1 is a ubiquitously expressed protein localized in nucleus, cytoplasm, as well as secreted into extracellular space. Nuclear HMGB1 binds to DNAs and RNAs, regulating genomic stability and transcription. Cytoplasmic HMGB1 regulates autophagy through binding… read more here.
Keywords: molecular insights; metabolic diseases; insights multifaceted; functions therapeutic ... See more keywords
Corrigendum: Histone deacetylase functions and therapeutic implications for adult skeletal muscle metabolism
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2023.1201886
Abstract: [This corrects the article DOI: 10.3389/fmolb.2023.1130183.]. read more here.
Keywords: corrigendum histone; functions therapeutic; implications adult; therapeutic implications ... See more keywords
Macrophages in Skin Wounds: Functions and Therapeutic Potential
Sign Up to like & getrecommendations! Published in 2022 at "Biomolecules"
DOI: 10.3390/biom12111659
Abstract: Macrophages regulate cutaneous wound healing by immune surveillance, tissue repair and remodelling. The depletion of dermal macrophages during the early and middle stages of wound healing has a detrimental impact on wound closure, characterised by… read more here.
Keywords: wound healing; wounds functions; macrophages skin; cutaneous wound ... See more keywords
KDEL Receptors: Pathophysiological Functions, Therapeutic Options, and Biotechnological Opportunities
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10061234
Abstract: KDEL receptors (KDELRs) are ubiquitous seven-transmembrane domain proteins encoded by three mammalian genes. They bind to and retro-transport endoplasmic reticulum (ER)-resident proteins with a C-terminal Lys-Asp-Glu-Leu (KDEL) sequence or variants thereof. In doing this, KDELR… read more here.
Keywords: kdel receptors; receptors pathophysiological; options biotechnological; functions therapeutic ... See more keywords