RIBOB: A study on the efficacy and safety of ribociclib in combination with letrozole in older women (≥70 years) with hormone receptor-positive (HR+) HER2-negative (HER2-) advanced breast cancer (aBC) with no prior systemic therapy for advanced disease
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DOI: 10.1093/annonc/mdz242.080
Abstract: Abstract Background Ribociclib in combination with endocrine therapy (ET) is the current standard of care in first-line for HR+/HER2- aBC. An increasing proportion of patients who are candidates for ribociclib are older (≥70 years of… read more here.
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JFMC51-1702-C7: Phase II study investigating efficacy and safety of trifluridine/tipiracil (FTD/TPI) plus bevacizumab (BEV) in patients (pts) with metastatic colorectal cancer (mCRC) refractory or intolerant to standard chemotherapies
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DOI: 10.1093/annonc/mdz246.096
Abstract: Abstract Background Combination treatment of FTD/TPI plus BEV in the C-TASK FORCE showed a promising activity in pts with mCRC refractory or intolerant to standard chemotherapies; however, due to the small sample size, it remains… read more here.
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FRONTiER: A feasibility trial of nivolumab with neoadjuvant CF or DCF therapy for locally advanced esophageal carcinoma
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DOI: 10.1093/annonc/mdz247.165
Abstract: Abstract Background The standard neoadjuvant chemotherapy (NAC) in Japan for locally advanced esophageal squamous cell cancer (ESCC) is chemotherapy with CDDP + 5-FU (CF). Docetaxel (DTX) + CF (DCF) is considered a promising regimen, which… read more here.
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Activity of the novel Aurora kinase B inhibitor AZD2811 in biomarker-defined models of small cell lung cancer
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DOI: 10.1093/annonc/mdz264.013
Abstract: Abstract Background Aurora Kinases (AURK) regulate mitosis and are often upregulated in cancer. SCLC is characterized by TP53 and RB1 loss and frequent MYC amplification. Our group, and others, have proved that MYC-driven SCLC are… read more here.
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Impact of immunotherapy and targeted therapy on tumour growth rate in sarcoma
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DOI: 10.1093/annonc/mdz283.043
Abstract: Abstract Background With increasing use of immunotherapy and targeted treatments in oncology, it is essential to understand the biological effects of these therapies on tumor kinetics. This retrospective review aims to identify hyperprogressive disease (HPD)… read more here.
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Timing of radiotherapy (RT) after radical prostatectomy (RP): First results from the RADICALS RT randomised controlled trial (RCT) [NCT00541047]
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DOI: 10.1093/annonc/mdz394.042
Abstract: Abstract Background The optimal timing of RT after RP for prostate cancer (PCa) is uncertain. RADICALS-RT compared the efficacy and safety of adjuvant RT (aRT) versus an observation policy with salvage RT for PSA failure… read more here.
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EORTC SPECTA-AYA: A molecular profiling platform for adolescents and young adults with cancer in Europe
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DOI: 10.1093/annonc/mdz413.123
Abstract: Abstract Background For most adolescent and young adult (AYA) cancers, age-specific molecular features are poorly understood. SPECTA, an academic translational research infrastructure for biomaterial collection and molecular analysis, will explicitly recruit AYA patients and will… read more here.
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