Our pursuit for effective antifungal agents targeting fungal cell wall components, where are we?
Sign Up to like & getrecommendations! Published in 2021 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2021.106477
Abstract: Invasive mycotic infections account for an unacceptably high mortality rates in humans. These infections are initiated by the fungal cell wall which mediates host-fungi interactions. The cell wall is fused to the physiology of fungi,… read more here.
Keywords: pursuit effective; antifungal agents; fungal cell; cell wall ... See more keywords
The Role of the Fungal Cell Wall in the Infection of Plants.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in microbiology"
DOI: 10.1016/j.tim.2017.05.015
Abstract: The polysaccharide-rich wall, which envelopes the fungal cell, is pivotal to the maintenance of cellular integrity and for the protection of the cell from external aggressors - such as environmental fluxes and during host infection.… read more here.
Keywords: role fungal; infection; wall; fungal cell ... See more keywords
Length specificity and polymerization mechanism of (1,3)-β-D-glucan synthase in fungal cell wall biosynthesis.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00896
Abstract: (1,3)-β-D-Glucan synthase (GS) catalyzes formation of the linear (1,3)-β-D-glucan in the fungal cell wall, and is a tar-get of clinically approved antifungal antibiotics. The catalytic subunit of GS, FKS protein, does not exhibit significant sequence… read more here.
Keywords: length; polymerization; synthase; mechanism ... See more keywords
Cell wall–associated effectors of plant-colonizing fungi
Sign Up to like & getrecommendations! Published in 2021 at "Mycologia"
DOI: 10.1080/00275514.2020.1831293
Abstract: ABSTRACT Plant-colonizing fungi secrete a cocktail of effector proteins during colonization. After secretion, some of these effectors are delivered into plant cells to directly dampen the plant immune system or redirect host processes benefitting fungal… read more here.
Keywords: wall associated; plant; plant colonizing; cell wall ... See more keywords
The Maize Pathogen Ustilago maydis Secretes Glycoside Hydrolases and Carbohydrate Oxidases Directed toward Components of the Fungal Cell Wall
Sign Up to like & getrecommendations! Published in 2022 at "Applied and Environmental Microbiology"
DOI: 10.1128/aem.01581-22
Abstract: Filamentous fungi play a central regulatory role on Earth, notably in the global carbon cycle. Regardless of their lifestyle, filamentous fungi need to remodel their own cell wall (mostly composed of polysaccharides) to grow and… read more here.
Keywords: maize pathogen; ustilago maydis; cell wall; fungal cell ... See more keywords
Fungal cell wall: An underexploited target for antifungal therapies
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1009470
Abstract: Cell wall architecture The cell wall of the major fungal pathogen Candida albicans consists of an outer layer that is made up of highly mannosylated proteins. The proteins are attached to the inner layer of… read more here.
Keywords: antifungal therapies; fungal cell; wall underexploited; cell wall ... See more keywords
Interactions between copper homeostasis and the fungal cell wall affect copper stress resistance
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010195
Abstract: Copper homeostasis mechanisms are essential for microbial adaption to changing copper levels within the host during infection. In the opportunistic fungal pathogen Cryptococcus neoformans (Cn), the Cn Cbi1/Bim1 protein is a newly identified copper binding… read more here.
Keywords: cell wall; fungal cell; copper;
What Are the Functions of Chitin Deacetylases in Aspergillus fumigatus?
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2020.00028
Abstract: Deacetylation of chitin by chitin deacetylases (Cda) results in the formation of chitosan. Chitosan, a polymer of β1,4 linked glucosamine, plays multiple roles in the function of the fungal cell wall, including virulence and evasion… read more here.
Keywords: aspergillus fumigatus; virulence; chitin deacetylases; cell wall ... See more keywords
Editorial: Fungal cell wall proteins with functions in cell wall biogenesis, cell wall signaling and interactions with host
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.1064386
Abstract: COPYRIGHT © 2022 Karkowska-Kuleta and Maddi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the… read more here.
Keywords: cell; wall proteins; cell wall; fungal cell ... See more keywords
Genetic Screening of Candida albicans Inactivation Mutants Identifies New Genes Involved in Macrophage-Fungal Cell Interactions
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.833655
Abstract: Candida albicans, an important fungal pathogen of humans, displays different morphologies, such as yeast, pseudo-hyphae and hyphae, which are recognized unequally by phagocytic cells of the innate immune response. Once C. albicans cells invade host… read more here.
Keywords: fungal cell; mutant; candida albicans; strains showed ... See more keywords
Structural Polymorphism of Chitin and Chitosan in Fungal Cell Walls From Solid-State NMR and Principal Component Analysis
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.727053
Abstract: Chitin is a major carbohydrate component of the fungal cell wall and a promising target for novel antifungal agents. However, it is technically challenging to characterize the structure of this polymer in native cell walls.… read more here.
Keywords: component; analysis; structure; chitin ... See more keywords