Engineering Strategies for Fungal Cell Disruption in Biotechnological Applications
Sign Up to like & getrecommendations! Published in 2025 at "Engineering in Life Sciences"
DOI: 10.1002/elsc.70061
Abstract: Fungal cell disruption plays a critical role in unlocking a wide range of high‐value intracellular products such as lipids, proteins, pigments, and bioactive compounds. However, lysing fungal cells is far more challenging than breaking bacterial… read more here.
Keywords: cell disruption; disruption; engineering strategies; fungal cell ... See more keywords
Our pursuit for effective antifungal agents targeting fungal cell wall components, where are we?
Sign Up to like & getrecommendations! Published in 2021 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2021.106477
Abstract: Invasive mycotic infections account for an unacceptably high mortality rates in humans. These infections are initiated by the fungal cell wall which mediates host-fungi interactions. The cell wall is fused to the physiology of fungi,… read more here.
Keywords: pursuit effective; antifungal agents; fungal cell; cell wall ... See more keywords
The Role of the Fungal Cell Wall in the Infection of Plants.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in microbiology"
DOI: 10.1016/j.tim.2017.05.015
Abstract: The polysaccharide-rich wall, which envelopes the fungal cell, is pivotal to the maintenance of cellular integrity and for the protection of the cell from external aggressors - such as environmental fluxes and during host infection.… read more here.
Keywords: role fungal; infection; wall; fungal cell ... See more keywords
Length specificity and polymerization mechanism of (1,3)-β-D-glucan synthase in fungal cell wall biosynthesis.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemistry"
DOI: 10.1021/acs.biochem.9b00896
Abstract: (1,3)-β-D-Glucan synthase (GS) catalyzes formation of the linear (1,3)-β-D-glucan in the fungal cell wall, and is a tar-get of clinically approved antifungal antibiotics. The catalytic subunit of GS, FKS protein, does not exhibit significant sequence… read more here.
Keywords: length; polymerization; synthase; mechanism ... See more keywords
A polyene macrolide targeting phospholipids in the fungal cell membrane
Sign Up to like & getrecommendations! Published in 2025 at "Nature"
DOI: 10.1038/s41586-025-08678-9
Abstract: The global spread of multidrug-resistant pathogenic fungi presents a serious threat to human health, necessitating the discovery of antifungals with unique modes of action1. However, conventional activity-based screening for previously undescribed antibiotics has been hampered… read more here.
Keywords: phospholipids fungal; polyene macrolide; mandimycin; fungal cell ... See more keywords
Structural and biochemical basis for activity of Aspergillus nidulans α-1,3-glucanases from glycoside hydrolase family 71
Sign Up to like & getrecommendations! Published in 2025 at "Communications Biology"
DOI: 10.1038/s42003-025-08696-3
Abstract: The microbial polysaccharide α-1,3-glucan is an important component of fungal cell walls and dental plaque biofilms, contributing to microbial virulence and biofilm resilience. Glycoside hydrolase family 71 (GH71) includes α-1,3-glucan degrading enzymes which could be… read more here.
Keywords: family; aspergillus nidulans; fungal cell; glycoside hydrolase ... See more keywords
α-glucan remodeling by GH13-domain enzymes shapes fungal cell wall architecture.
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2505509122
Abstract: Significance Fungal cell walls are essential for growth, division, and survival, and are prime targets for antifungal therapy. Here, we identify two conserved α-amylase-like enzymes, Aah1 and Aah3, as redundant key contributors to α-glucan remodeling… read more here.
Keywords: cell wall; fungal cell; cell; glucan remodeling ... See more keywords
Cell wall–associated effectors of plant-colonizing fungi
Sign Up to like & getrecommendations! Published in 2021 at "Mycologia"
DOI: 10.1080/00275514.2020.1831293
Abstract: ABSTRACT Plant-colonizing fungi secrete a cocktail of effector proteins during colonization. After secretion, some of these effectors are delivered into plant cells to directly dampen the plant immune system or redirect host processes benefitting fungal… read more here.
Keywords: wall associated; plant; plant colonizing; cell wall ... See more keywords
The Maize Pathogen Ustilago maydis Secretes Glycoside Hydrolases and Carbohydrate Oxidases Directed toward Components of the Fungal Cell Wall
Sign Up to like & getrecommendations! Published in 2022 at "Applied and Environmental Microbiology"
DOI: 10.1128/aem.01581-22
Abstract: Filamentous fungi play a central regulatory role on Earth, notably in the global carbon cycle. Regardless of their lifestyle, filamentous fungi need to remodel their own cell wall (mostly composed of polysaccharides) to grow and… read more here.
Keywords: maize pathogen; ustilago maydis; cell wall; fungal cell ... See more keywords
Fungal cell wall: An underexploited target for antifungal therapies
Sign Up to like & getrecommendations! Published in 2021 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1009470
Abstract: Cell wall architecture The cell wall of the major fungal pathogen Candida albicans consists of an outer layer that is made up of highly mannosylated proteins. The proteins are attached to the inner layer of… read more here.
Keywords: antifungal therapies; fungal cell; wall underexploited; cell wall ... See more keywords
Interactions between copper homeostasis and the fungal cell wall affect copper stress resistance
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010195
Abstract: Copper homeostasis mechanisms are essential for microbial adaption to changing copper levels within the host during infection. In the opportunistic fungal pathogen Cryptococcus neoformans (Cn), the Cn Cbi1/Bim1 protein is a newly identified copper binding… read more here.
Keywords: cell wall; fungal cell; copper;