Overcoming the Stromal Barrier of the Cornea with a Peptide Conjugate Nano‐Assembly to Combat Fungal Keratitis
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202202409
Abstract: Fungal hyphae deeply invade the cornea in fungal keratitis. The corneal stroma hinders the infiltration of antifungal drugs and reduces their bioavailability. Here, this work reports a peptide conjugate nano‐assembly that permeates the stroma and… read more here.
Keywords: fungal keratitis; cornea; nano; nano assembly ... See more keywords
Visualized Gallium/Lyticase‐Integrated Antifungal Strategy for Fungal Keratitis Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202206437
Abstract: Fungal keratitis has been one of the common corneal infections that causes blindness, but an effective antifungal strategy remains a challenge. The exopolysaccharides both in the fungal cell walls and biofilms are a key that… read more here.
Keywords: keratitis; antifungal strategy; fungal keratitis; treatment ... See more keywords
Interface Scopulariopsis gracilis fungal keratitis following Descemet’s stripping automated endothelial keratoplasty (DSAEK) with a contaminated graft
Sign Up to like & getrecommendations! Published in 2017 at "International Ophthalmology"
DOI: 10.1007/s10792-017-0706-0
Abstract: PurposeTo report for the first time a case of interface Scopulariopsis gracilis fungal keratitis following Descemet’s stripping automated endothelial keratoplasty (DSAEK) with a contaminated graft.MethodsA 57-year-old man with bilateral keratoconus and previous bilateral penetrating keratoplasties… read more here.
Keywords: gracilis; scopulariopsis gracilis; gracilis fungal; contaminated graft ... See more keywords
Ocular surface squamous neoplasia in a setting of fungal keratitis: a rare co-occurrence
Sign Up to like & getrecommendations! Published in 2018 at "International Ophthalmology"
DOI: 10.1007/s10792-018-0864-8
Abstract: AbstractPurposeTo describe a rare co-occurrence of ocular surface squamous neoplasia (OSSN) in a patient with microbial keratitis.MethodsCase report.ResultsWe describe a 68-years female who developed ocular surface squamous neoplasia (OSSN) in an eye with culture proven… read more here.
Keywords: ocular surface; surface; occurrence; fungal keratitis ... See more keywords
Epidemiology, clinical profile and treatment outcomes of bacterial and fungal keratitis
Sign Up to like & getrecommendations! Published in 2021 at "International Ophthalmology"
DOI: 10.1007/s10792-021-02128-x
Abstract: The purpose of the study is to determine the microbiological etiology, epidemiological factors, and clinical profile and treatment outcomes of infective keratitis in Ophthalmology department, Minia University, Egypt. Prospective, nonrandomized, observational clinical series of cases,… read more here.
Keywords: ophthalmology; epidemiology; fungal keratitis; bacterial fungal ... See more keywords
Indolent keratitis due to fungus of Malbranchea species. A case report
Sign Up to like & getrecommendations! Published in 2020 at "Annals of Medicine and Surgery"
DOI: 10.1016/j.amsu.2020.11.065
Abstract: Introduction Keratitis caused by saprophytic fungi is on the rise in rural areas, often caused by ocular trauma with wooden objects. Early detection of causative organisms and sustained, supervised management can prevent visual disabilities. Case… read more here.
Keywords: case; report; fungal keratitis; malbranchea species ... See more keywords
A novel 3D culture model of fungal keratitis to explore host-pathogen interactions within the stromal environment.
Sign Up to like & getrecommendations! Published in 2021 at "Experimental eye research"
DOI: 10.1016/j.exer.2021.108581
Abstract: Fungal keratitis (FK) pathology is driven by both fungal growth and inflammation within the corneal stroma. Standard in vitro infection models ̶ involving co-culture of the pathogen and the corneal cells in tissue culture medium… read more here.
Keywords: culture model; culture; host; fungal keratitis ... See more keywords
Candida dubliniensis: A novel cause of fungal keratitis
Sign Up to like & getrecommendations! Published in 2018 at "IDCases"
DOI: 10.1016/j.idcr.2018.e00440
Abstract: A 45-year-old female with history of contact lens wear presented with a persistent corneal ulcer that was unresponsive to topical moxifloxacin. The patient’s exam was concerning for fungal keratitis. Cultures were obtained, and the patient… read more here.
Keywords: dubliniensis novel; dubliniensis; cause; candida dubliniensis ... See more keywords
Enhanced in vivo antifungal activity of novel cell penetrating peptide Natamycin conjugate for efficient fungal keratitis management.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2021.120484
Abstract: Natamycin is the only FDA approved drug that is used as a first line of treatment for fungal keratitis caused by filamentous fungi, however natamycin is known for poor corneal penetration. Cell penetrating peptides (CPPs)… read more here.
Keywords: conjugate; penetration; cell penetrating; fungal keratitis ... See more keywords
Therapeutic effects of an anti-IL-6 antibody in fungal keratitis: Macrophage inhibition and T cell subset regulation.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106649
Abstract: Immune modulation plays a critical role in the pathogenesis of fungal keratitis (FK). However, the immune cell-mediated processes linking the innate immune response to the adaptive immune response are incompletely elucidated. IL-6 plays crucial roles… read more here.
Keywords: therapeutic effects; macrophage; fungal keratitis; cell ... See more keywords
Flavopiridol Protects against Fungal Keratitis due to Aspergillus fumigatus by Alleviating Inflammation through the Promotion of Autophagy.
Sign Up to like & getrecommendations! Published in 2022 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.2c00427
Abstract: Fungal keratitis is a serious infectious keratopathy related to fungal virulence and excessive inflammatory responses. Autophagy exhibits a potent ability to resolve inflammation during fungal infection. This study aimed to investigate the protective function of… read more here.
Keywords: inflammation; 264 cells; aspergillus fumigatus; fungal keratitis ... See more keywords