Total Synthesis and Bioactivity Studies of Fungal Metabolite (-)-TAN-2483B.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c03303
Abstract: The first total synthesis of (-)-TAN-2483B, a fungal metabolite possessing a densely functionalized furo[3,4-b]pyran-5-one framework, is achieved in 14 steps from d-mannose. Generation of the 2,6-trans-pyran is by cyclopropane ring expansion followed by α-selective alkynylation.… read more here.
Keywords: total synthesis; synthesis bioactivity; tan 2483b; fungal metabolite ... See more keywords
Asperspiropene A, a novel fungal metabolite as an inhibitor of cancer-associated mutant isocitrate dehydrogenase 1
Sign Up to like & getrecommendations! Published in 2017 at "Organic chemistry frontiers"
DOI: 10.1039/c6qo00847j
Abstract: In silico screening of an in-house natural product database and confirmatory bioassays led to the identification of asperspiropene A (1) as an inhibitor of cancer-associated mutant IDH1. Compound 1, a meroterpenoid with a highly functionalized… read more here.
Keywords: inhibitor cancer; cancer associated; associated mutant; fungal metabolite ... See more keywords
Proposing a fungal metabolite-flaviolin as a potential inhibitor of 3CLpro of novel coronavirus SARS-CoV-2 identified using docking and molecular dynamics
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2020.1813202
Abstract: Abstract The novel SARS-CoV-2 is the etiological agent causing the Coronavirus disease 2019 (COVID-19), which continues to become an inevitable pandemic outbreak. Over a short span of time, the structures of therapeutic target proteins for… read more here.
Keywords: sars cov; fungal metabolite; cov identified; inhibitor 3clpro ... See more keywords
Antioxidant, antimicrobial and antiproliferative activities of fungal metabolite produced by Aspergillus flavus on in vitro study
Sign Up to like & getrecommendations! Published in 2021 at "Food Science and Technology"
DOI: 10.1590/fst.01421
Abstract: Abstract Regarding to the defiance came upon scientists to output natural products with potent biological activity from cheap sources and in an attempt to recover the average of antiproliferative agents, the employment of fungal metabolite… read more here.
Keywords: fungal metabolite; antiproliferative activities; antimicrobial antiproliferative; aspergillus flavus ... See more keywords