Preparation of a Ribosomally Synthesized Fungal Peptide Toxin Precursor and its in-vitro Cyclization.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of biotechnology"
DOI: 10.1016/j.jbiotec.2019.12.004
Abstract: Amatoxins are ribosomally synthesized and post-translationally modified peptides (RiPPs) found in poisonous mushrooms. These cyclic peptides are potent inhibitors of RNA polymerase II transcriptional activity. Though the macrocyclization of amatoxin is extensively studied, little is… read more here.
Keywords: peptide toxin; fungal peptide; preparation ribosomally; synthesized fungal ... See more keywords
Substrate Plasticity of a Fungal Peptide α-N-Methyltransferase
Sign Up to like & getrecommendations! Published in 2020 at "ACS Chemical Biology"
DOI: 10.1021/acschembio.0c00237
Abstract: The methylation of amide nitrogen atoms can improve the stability, oral availability, and cell permeability of peptide therapeutics. Chemical N-methylation of peptides is challenging. Omphalotin A is a ribosomally synthesized, macrocylic dodecapeptide with nine backbone… read more here.
Keywords: peptide methyltransferase; peptide; fungal peptide; methyltransferase ... See more keywords