Articles with "fungal selective" as a keyword



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Design and synthesis of fungal-selective resorcylate aminopyrazole Hsp90 inhibitors.

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Published in 2019 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.9b00826

Abstract: The molecular chaperone Hsp90, essential in all eukaryotes, plays a multifaceted role in promoting survival, virulence and drug resistance across diverse pathogenic fungal species. The chaperone is also critically important, however, to the pathogen's human… read more here.

Keywords: design synthesis; fungal selective; hsp90; hsp90 inhibitors ... See more keywords