Fungal statin pump protein improves monacolin J efflux and regulates its production in Komagataella phaffii
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DOI: 10.1186/s40643-020-00321-x
Abstract: Monacolin J (MJ) is a key intermediate for the synthesis of cholesterol-lowering drug simvastatin. Current industrial production of MJ involves complicated chemical hydrolysis of microbial fermented lovastatin. Recently, heterologous production of MJ has been achieved… read more here.
Keywords: statin pump; fungal statin; production; tapa ... See more keywords