Miltefosine is fungicidal to Paracoccidioides spp. yeast cells but subinhibitory concentrations induce melanisation.
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DOI: 10.1016/j.ijantimicag.2016.12.020
Abstract: Paracoccidioidomycosis (PCM) is a systemic mycosis caused by the dimorphic fungi Paracoccidioides spp. The duration of antifungal treatment ranges from months to years and relapses may nevertheless occur despite protracted therapy. Thus, there remains an… read more here.
Keywords: subinhibitory concentration; fungicidal paracoccidioides; paracoccidioides spp; miltefosine fungicidal ... See more keywords