Overexpression of the pro-protein convertase furin predicts prognosis and promotes papillary thyroid carcinoma progression and metastasis through RAF/MEK signaling.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13396
Abstract: Furin belongs to the pro-protein convertases (PCs) family and its aberrant expression has been documented in various types of cancers; however, its role in thyroid cancer remains unclear. We investigated the expression of furin in… read more here.
Keywords: thyroid carcinoma; furin; ptc; braf ... See more keywords
Targeted Delivery of an Activatable Fluorescent Probe for the Detection of Furin Activity in Living Cells
Sign Up to like & getrecommendations! Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201800015
Abstract: Furin, a protein convertase, plays a crucial role in the progression of tumors. In this work, a new fluorescent probe consisting of a peptide, Arg‐Val‐Arg‐Arg (RVRR), and an aminoluciferin fluorophore was designed and prepared for… read more here.
Keywords: probe; detection furin; furin; furin activity ... See more keywords
The positive feedback loop of furin and TGFβ1 enhances the immune responses of Tregs to hepatocellular carcinoma cells and hepatitis B virus in vitro
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11806
Abstract: Regulatory T cells (Tregs) can exert immunosuppressive activity. Furin can regulate Treg functions, hepatitis B virus (HBV) persistent infection, and hepatocellular carcinoma (HCC) development. However, it remains unknown whether furin can regulate the immune responses… read more here.
Keywords: hbv1 hepg2; furin tgf; furin; hepg2 cells ... See more keywords
Optimization of Substrate‐Analogue Furin Inhibitors
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DOI: 10.1002/cmdc.201700596
Abstract: The proprotein convertase furin is a potential target for drug design, especially for the inhibition of furin‐dependent virus replication. All effective synthetic furin inhibitors identified thus far are multibasic compounds; the highest potency was found… read more here.
Keywords: substrate analogue; optimization substrate; potency; furin inhibitors ... See more keywords
Furin promotes dendritic morphogenesis and learning and memory in transgenic mice
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-017-2742-3
Abstract: Furin is a proprotein convertase implicated in a variety of pathological processes including neurodegenerative diseases. However, the role of furin in neuronal plasticity and learning and memory remains to be elucidated. Here, we report that… read more here.
Keywords: learning memory; furin; morphogenesis learning; mice ... See more keywords
FURIN correlated with immune infiltration serves as a potential biomarker in SARS-CoV-2 infection-related lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2021 at "Clinical and Experimental Medicine"
DOI: 10.1007/s10238-021-00760-6
Abstract: FURIN, as a proprotein convertase, has been found to be expressed in a variety of cancers and plays an important role in cancer. In addition, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires FURIN to… read more here.
Keywords: furin; sars cov; lung adenocarcinoma; expression ... See more keywords
Structural characteristics of Heparan sulfate required for the binding with the virus processing Enzyme Furin
Sign Up to like & getrecommendations! Published in 2021 at "Glycoconjugate Journal"
DOI: 10.1007/s10719-021-10018-8
Abstract: Furin is one of the nine-member proprotein convertase family. Furin cleaves proteins with polybasic residues, which includes many viral glycoproteins such as SARS-Cov-2 spike protein. The cleavage is required for the activation of the proteins.… read more here.
Keywords: structural characteristics; heparan sulfate; furin; sulfation ... See more keywords
Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.04.063
Abstract: Guanylate-binding protein (GBP) 5 is an interferon (IFN)-inducible cellular factor reducing HIV-1 infectivity by an incompletely understood mechanism. Here, we show that this activity is shared by GBP2, but not by other members of the… read more here.
Keywords: exert broad; broad antiviral; guanylate binding; envelope ... See more keywords
Higher binding affinity of furin for SARS-CoV-2 spike (S) protein D614G mutant could be associated with higher SARS-CoV-2 infectivity
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Infectious Diseases"
DOI: 10.1016/j.ijid.2020.10.033
Abstract: Objective The coronavirus disease-19 (COVID-19) pandemic has caused an exponential rise in death rates and hospitalizations. The aim of this study was to characterize the D614 G mutation of SARS-CoV-2 S-protein, which may affect viral infectivity.… read more here.
Keywords: protein; d614 mutation; furin; sars cov ... See more keywords
Near-Infrared Fluorescent Furin Probe for Revealing the Role of Furin in Cellular Carcinogenesis and Specific Cancer Imaging.
Sign Up to like & getrecommendations! Published in 2019 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.9b01220
Abstract: Furin, an important member in the family of proprotein convertases, is a participant in the activation of various precursor proteins. The expression level of furin stays in a very low range in most normal cells,… read more here.
Keywords: probe; near infrared; furin; specific cancer ... See more keywords
Self-Assembly of Amphiphilic Peptides for Recognizing High Furin-Expressing Cancer Cells.
Sign Up to like & getrecommendations! Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.9b01281
Abstract: Self-assembled nanostructures of amphiphilic peptides have a wide range of applications in bioimaging and delivery systems. In this study, we design and synthesize a biocompatible amphiphilic peptide (C-3) consisting of an RVRRFFF sequence and a… read more here.
Keywords: self assembly; furin expressing; furin; high furin ... See more keywords