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   Articles with "furin inhibitors" as a keyword



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Optimization of Substrate‐Analogue Furin Inhibitors

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recommendations! Published in 2017 at "ChemMedChem"

DOI: 10.1002/cmdc.201700596

Abstract: The proprotein convertase furin is a potential target for drug design, especially for the inhibition of furin‐dependent virus replication. All effective synthetic furin inhibitors identified thus far are multibasic compounds; the highest potency was found… read more here.

Keywords: substrate analogue; optimization substrate; potency; furin inhibitors ... See more keywords
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Cyclic Peptidic Furin Inhibitors Developed by Combinatorial Chemistry.

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recommendations! Published in 2023 at "ACS medicinal chemistry letters"

DOI: 10.1021/acsmedchemlett.3c00008

Abstract: Furin is a human serine protease responsible for activating numerous physiologically relevant cell substrates and is also involved in the development of various pathological conditions, including inflammatory diseases, cancers, and viral and bacterial infections. Therefore,… read more here.

Keywords: furin; combinatorial chemistry; chemistry; inhibitor ... See more keywords
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Theta-Defensins to Counter COVID-19 as Furin Inhibitors: In Silico Efficiency Prediction and Novel Compound Design

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recommendations! Published in 2022 at "Computational and Mathematical Methods in Medicine"

DOI: 10.1155/2022/9735626

Abstract: Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was characterized as a pandemic by the World Health Organization (WHO) in Dec. 2019. SARS-CoV-2 binds to the cell membrane through spike… read more here.

Keywords: furin inhibitors; covid furin; theta defensins; furin ... See more keywords
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Identification of Kukoamine A, Zeaxanthin, and Clexane as New Furin Inhibitors

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recommendations! Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms23052796

Abstract: The endogenous protease furin is a key protein in many different diseases, such as cancer and infections. For this reason, a wide range of studies has focused on targeting furin from a therapeutic point of… read more here.

Keywords: furin inhibitors; zeaxanthin clexane; furin; clexane new ... See more keywords