Synthesis of some substituted furo[3,2-g]chromeno[2,3-c]pyrazole and pyrazoline derivatives from 5-hydroxybergapten and 5-hydroxyisopimpinellin as EGFR and VEGFR-2 kinase inhibitors
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DOI: 10.1134/s1070363217070258
Abstract: A series of substituted 7H-furo[3,2-g]chromen-7-one and furo[3,2-g]chromeno[2,3-c]pyrazole derivatives (2–9) were synthesized by using 5-hydroxy-4-methoxy-7H-furo[3,2-g]chromen-7-one (5-hydroxybergapten) and 5-hydroxy-4,9-dimethoxy-7H-furo[3,2-g]chromen-7-one (5-hydroxyisopimpinellin) (1) as starting materials. Compound 1 reacted with amino acid esters to give the corresponding 5-N-amino acid… read more here.
Keywords: substituted furo; furo chromeno; egfr vegfr; pyrazoline ... See more keywords