Furosemide suppresses ileal and colonic contractility via interactions with GABA‐A receptor in mice
Sign Up to like & getrecommendations! Published in 2017 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.12824
Abstract: The loop diuretic furosemide has an action to inhibit Na+–K+–2Cl− co‐transporter at the thick ascending limb of Henle's loop resulting in diuresis. Furosemide also has the non‐diuretic effects by binding to GABA‐A receptor which may… read more here.
Keywords: furosemide; gaba receptor; contraction; receptor ... See more keywords
Furosemide depresses the presynaptic fiber volley and modifies frequency-dependent axonal excitability in rat hippocampus.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of neurophysiology"
DOI: 10.1152/jn.00704.2016
Abstract: The loop diuretic furosemide is known to have anticonvulsant effects, believed to be exerted through blockade of glial Na+-K+-2Cl- cotransport causing altered volume regulation in brain tissue. The possibility that direct effects of furosemide on… read more here.
Keywords: fiber volley; furosemide; axonal excitability; excitability ... See more keywords
Abstract 17177: Furosemide Promotes Myocardial Fibrosis in Swine Heart Failure
Sign Up to like & getrecommendations! Published in 2020 at "Circulation"
DOI: 10.1161/circ.142.suppl_3.17177
Abstract: Introduction: Although frequently used in heart failure (HF), long-term furosemide exacerbates HF in a swine model. This paradoxical phenomenon may reflect furosemide-induced alterations in signaling proteins of the extracellular matrix (ECM) to increase fibrosis. Examination… read more here.
Keywords: fibrosis; control; furosemide; heart failure ... See more keywords
Preparation and Characterization of Furosemide Solid Dispersion with Enhanced Solubility and Bioavailability
Sign Up to like & getrecommendations! Published in 2022 at "AAPS PharmSciTech"
DOI: 10.1208/s12249-022-02208-w
Abstract: Furosemide (FMD), as a potent circulating diuretic, is commonly used for the treatment of hypertension and edema arising from cardiac, renal, and hepatic failure. However, the low solubility of furosemide restricts its dissolution and bioavailability.… read more here.
Keywords: furosemide; solubility; pvp k30; solid dispersion ... See more keywords
Cumulative Doses Predict the Risk of Furosemide-Induced Electrolyte Abnormalities in Critically Ill Neonates
Sign Up to like & getrecommendations! Published in 2022 at "Therapeutics and Clinical Risk Management"
DOI: 10.2147/tcrm.s369737
Abstract: Background Furosemide has limited indications in the term neonates. Its use in preterm neonates is off-label. Considering the dearth of data, we carried out a retrospective study evaluating the furosemide use and its effects on… read more here.
Keywords: ill neonates; critically ill; cumulative doses; furosemide ... See more keywords
Different Effects on Fluid Distribution between Tolvaptan and Furosemide in a Liver Cirrhosis Patient with Chronic Kidney Disease
Sign Up to like & getrecommendations! Published in 2019 at "Internal Medicine"
DOI: 10.2169/internalmedicine.2174-18
Abstract: A 73-year-old man with liver cirrhosis and advanced chronic kidney disease was admitted to our hospital due to bilateral lower leg edema and appetite loss. Furosemide to treat fluid retention markedly decreased extracellular water compared… read more here.
Keywords: tolvaptan; chronic kidney; furosemide; different effects ... See more keywords
Is furosemide a nephrotoxic for hospitalized patients?
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Renal Injury Prevention"
DOI: 10.34172/jrip.2023.32164
Abstract: Introduction: Acute kidney disease (AKI) is preventable in certain situations. Long-term and/or high dose furosemide may lead to acute kidney injury. Objectives: We aimed to find the risk of AKI among hospitalised patients who were… read more here.
Keywords: acute kidney; kidney; kidney injury; furosemide ... See more keywords
Incidence of Sterile Hemorrhagic Cystitis in Dogs Treated with Cyclophosphamide and Low-Dose Furosemide.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of the American Animal Hospital Association"
DOI: 10.5326/jaaha-ms-7169
Abstract: Cyclophosphamide is a commonly used chemotherapy in the treatment of lymphoma. It can cause sterile hemorrhagic cystitis (SHC), and furosemide is used to decrease the incidence of SHC. The aim of this study is to… read more here.
Keywords: incidence; shc; dose furosemide; furosemide ... See more keywords
Subcutaneous infusión of furosemide administered by elastomeric pumps for decompensated heart failure treatment after discharge. Coordination between Cardiology, Comunity nurses and telecare data
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Integrated Care"
DOI: 10.5334/ijic.3711
Abstract: Managing Heart Failure (HF) consumes more than 1% of the healthcare budget and two-thirds of this expenditure is due to hospitalizations. Diuretics are the main treatment and furosemide is the most commonly used drug. The… read more here.
Keywords: cardiology; furosemide; treatment; heart failure ... See more keywords
Small molecule therapeutics for COVID-19: repurposing of inhaled furosemide
Sign Up to like & getrecommendations! Published in 2020 at "PeerJ"
DOI: 10.7717/peerj.9533
Abstract: The novel coronavirus SARS-CoV-2 has become a global health concern. The morbidity and mortality of the potentially lethal infection caused by this virus arise from the initial viral infection and the subsequent host inflammatory response.… read more here.
Keywords: anti inflammatory; repurposing inhaled; furosemide; small molecule ... See more keywords