LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "fus" as a keyword



Photo by chriscurry92 from unsplash

FUS causes synaptic hyperexcitability in Drosophila dendritic arborization neurons

Sign Up to like & get
recommendations! Published in 2018 at "Brain Research"

DOI: 10.1016/j.brainres.2018.03.037

Abstract: Mutations in the nuclear localization signal of the RNA binding protein FUS cause both Frontotemporal Dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS). These mutations result in a loss of FUS from the nucleus and the… read more here.

Keywords: drosophila; hyperexcitability; caz; fus ... See more keywords
Photo from wikipedia

Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites

Sign Up to like & get
recommendations! Published in 2018 at "Cell"

DOI: 10.1016/j.cell.2018.03.003

Abstract: Liquid-liquid phase separation (LLPS) is believed to underlie formation of biomolecular condensates, cellular compartments that concentrate macromolecules without surrounding membranes. Physical mechanisms that control condensate formation/dissolution are poorly understood. The RNA-binding protein fused in sarcoma… read more here.

Keywords: phase separation; fus; receptor inhibits; import receptor ... See more keywords
Photo by heydedesign from unsplash

Antiviral Immune Response as a Trigger of FUS Proteinopathy in Amyotrophic Lateral Sclerosis

Sign Up to like & get
recommendations! Published in 2019 at "Cell Reports"

DOI: 10.1016/j.celrep.2019.11.094

Abstract: Summary Mutations in the FUS gene cause familial amyotrophic lateral sclerosis (ALS-FUS). In ALS-FUS, FUS-positive inclusions are detected in the cytoplasm of neurons and glia, a condition known as FUS proteinopathy. Mutant FUS incorporates into… read more here.

Keywords: fus; fus proteinopathy; amyotrophic lateral; immune response ... See more keywords
Photo by averey from unsplash

Dendritic Homeostasis Disruption in a Novel Frontotemporal Dementia Mouse Model Expressing Cytoplasmic Fused in Sarcoma

Sign Up to like & get
recommendations! Published in 2017 at "EBioMedicine"

DOI: 10.1016/j.ebiom.2017.09.005

Abstract: Cytoplasmic aggregation of fused in sarcoma (FUS) is detected in brain regions affected by amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), which compose the disease spectrum, FUS proteinopathy. To understand the pathomechanism of ALS-FTD-associated… read more here.

Keywords: frontotemporal dementia; dendritic homeostasis; fus; homeostasis disruption ... See more keywords
Photo by edenconstantin0 from unsplash

Physical blood‐brain barrier disruption induced by focused ultrasound does not overcome the transporter‐mediated efflux of erlotinib

Sign Up to like & get
recommendations! Published in 2018 at "Journal of Controlled Release"

DOI: 10.1016/j.jconrel.2018.11.009

Abstract: &NA; Overcoming the efflux mediated by ATP–binding cassette (ABC) transporters at the blood‐brain barrier (BBB) remains a challenge for the delivery of small molecule tyrosine kinase inhibitors (TKIs) such as erlotinib to the brain. Inhibition… read more here.

Keywords: disruption; fus; erlotinib; bbb disruption ... See more keywords
Photo by alinnnaaaa from unsplash

ALS/FTD-Linked Mutation in FUS Suppresses Intra-axonal Protein Synthesis and Drives Disease Without Nuclear Loss-of-Function of FUS

Sign Up to like & get
recommendations! Published in 2020 at "Neuron"

DOI: 10.1016/j.neuron.2020.04.006

Abstract: Jone López-Erauskin, Takahiro Tadokoro, Michael W. Baughn, Brian Myers, Melissa McAlonis-Downes, Carlos Chillon-Marinas, JoshuaN. Asiaban, Jonathan Artates, Anh T. Bui, Anne P. Vetto, Sandra K. Lee, Ai Vy Le, Ying Sun, Mélanie Jambeau, Jihane Boubaker,… read more here.

Keywords: fus suppresses; fus; mutation fus; linked mutation ... See more keywords
Photo by soberanes from unsplash

Cognitive Versus Software Fusion for MRI-targeted Biopsy: Experience Before and After Implementation of Fusion.

Sign Up to like & get
recommendations! Published in 2018 at "Urology"

DOI: 10.1016/j.urology.2018.06.011

Abstract: OBJECTIVE To compare the diagnostic performance of the 2 most common approaches of magnetic resonance imaging targeted biopsy (TB)-cognitive registration targeted biopsy (COG-TB) and software fusion targeted biopsy (FUS-TB)-we assessed our institutional experience with both… read more here.

Keywords: cog; experience; fus; fusion ... See more keywords
Photo from wikipedia

Benchmarking Molecular Dynamics Force Fields for All-Atom Simulations of Biological Condensates.

Sign Up to like & get
recommendations! Published in 2023 at "Journal of chemical theory and computation"

DOI: 10.1021/acs.jctc.3c00148

Abstract: Proteins containing intrinsically disordered regions are integral parts of the cellular signaling pathways and common components of biological condensates. Point mutations in the protein sequence, genetic at birth or acquired through aging, can alter the… read more here.

Keywords: molecular dynamics; force fields; force; biological condensates ... See more keywords
Photo from wikipedia

Probing Cerebral Metabolism with Hyperpolarized 13C Imaging after Opening the Blood-Brain Barrier with Focused Ultrasound.

Sign Up to like & get
recommendations! Published in 2021 at "ACS chemical neuroscience"

DOI: 10.1021/acschemneuro.1c00197

Abstract: Transient disruption of the blood-brain barrier (BBB) with focused ultrasound (FUS) is an emerging clinical method to facilitate targeted drug delivery to the brain. The focal noninvasive disruption of the BBB can be applied to… read more here.

Keywords: 13c imaging; bbb; fus; delivery ... See more keywords
Photo from wikipedia

Antisense oligonucleotide silencing of FUS expression as a therapeutic approach in amyotrophic lateral sclerosis

Sign Up to like & get
recommendations! Published in 2022 at "Nature Medicine"

DOI: 10.1038/s41591-021-01615-z

Abstract: Fused in sarcoma (FUS) is an RNA-binding protein that is genetically and pathologically associated with rare and aggressive forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). To explore the mechanisms by which mutant… read more here.

Keywords: lateral sclerosis; amyotrophic lateral; antisense oligonucleotide; fus ... See more keywords
Photo from wikipedia

Proteomics analysis of FUS mutant human motoneurons reveals altered regulation of cytoskeleton and other ALS-linked proteins via 3′UTR binding

Sign Up to like & get
recommendations! Published in 2020 at "Scientific Reports"

DOI: 10.1038/s41598-020-68794-6

Abstract: Increasing evidence suggests that in Amyotrophic Lateral Sclerosis (ALS) mutated RNA binding proteins acquire aberrant functions, leading to altered RNA metabolism with significant impact on encoded protein levels. Here, by taking advantage of a human… read more here.

Keywords: cytoskeleton; mutant fus; fus; proteomics analysis ... See more keywords