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   Articles with "fus als" as a keyword



Brain Metabolic Features of FUS‐ALS: A 2‐[ 18F]FDG‐PET Study

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recommendations! Published in 2025 at "Annals of Neurology"

DOI: 10.1002/ana.27201

Abstract: We aimed at evaluating the brain metabolic features of fused in sarcoma amyotrophic lateral sclerosis (FUS‐ALS) compared with sporadic ALS (sALS), using 2‐[fluorine‐18] fluoro‐2‐deoxy‐D‐glucose positron emission tomography (2‐[18F]FDG‐PET). read more here.

Keywords: fdg pet; fus als; 18f fdg; brain metabolic ... See more keywords

Potential Therapeutic Role of HDAC Inhibitors in FUS-ALS

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recommendations! Published in 2021 at "Frontiers in Molecular Neuroscience"

DOI: 10.3389/fnmol.2021.686995

Abstract: Mutations in the FUS gene cause amyotrophic lateral sclerosis (ALS-FUS). However, the exact pathogenic mechanism of mutant fused in sarcoma (FUS) protein is not completely understood. FUS is an RNA binding protein (RBP) localized predominantly… read more here.

Keywords: fus; hdac inhibitors; role; inhibitors fus ... See more keywords

Quantitative Immunofluorescence Mapping of HSP70’s Neuroprotective Effects in FUS-ALS Mouse Models

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recommendations! Published in 2024 at "Applied Sciences"

DOI: 10.3390/app142411614

Abstract: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease, often linked to mutations in the FUS gene, leading to toxic protein aggregates. This study investigates the role of HSP70, a molecular chaperone, in mitigating neurodegeneration… read more here.

Keywords: mouse models; hsp70; fus als; als mouse ... See more keywords

Interleukin-17 and Th17 Lymphocytes Directly Impair Motoneuron Survival of Wildtype and FUS-ALS Mutant Human iPSCs

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recommendations! Published in 2021 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms22158042

Abstract: Amyotrophic lateral sclerosis (ALS) is a progressive disease leading to the degeneration of motor neurons (MNs). Neuroinflammation is involved in the pathogenesis of ALS; however, interactions of specific immune cell types and MNs are not… read more here.

Keywords: th17 cells; th17 lymphocytes; th17; degeneration ... See more keywords