Abstract 5631: YAP1 is a critical factor for FUS::DDIT3/BAF/c-Jun complex assembly in myxoid liposarcoma
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DOI: 10.1158/1538-7445.am2024-5631
Abstract: Introduction: FUS::DDIT3 is the dominant fusion protein in myxoid liposarcoma (MLS), resulting from a disease-defining chromosomal translocation. Acting as an aberrant transcription factor, FUS::DDIT3 disturbs gene regulatory networks interfering with adipogenic differentiation, while driving oncogenic… read more here.
Keywords: fus ddit3; ddit3; factor; mls ... See more keywords
FUS::DDIT3 Fusion Protein in the Development of Myxoid Liposarcoma and Possible Implications for Therapy
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DOI: 10.3390/biom14101297
Abstract: The FUS::DDIT3 fusion protein, formed by the chromosomal translocation t (12;16) (q13;p11), is found in over 90% of myxoid liposarcoma (MLS) cases and is a crucial protein in its development. Many studies have explored the… read more here.
Keywords: ddit3 fusion; ddit3; fusion protein; fus ddit3 ... See more keywords