Synthesis of heterocyclic ring-fused analogs of HMG499 as novel degraders of HMG-CoA reductase that lower cholesterol.
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DOI: 10.1016/j.ejmech.2022.114323
Abstract: HMG-CoA reductase (HMGCR) is the rate-limiting enzyme in cholesterol de novo biosynthesis and its degradation may bring therapeutic benefits for the treatment of cardiovascular disease (CVD) and nonalcoholic steatohepatitis (NASH). Before, we disclosed compound HMG499… read more here.
Keywords: heterocyclic ring; fused analogs; cholesterol; ring fused ... See more keywords