Synthesis and Biological Evaluation of C-17-Amino-Substituted Pyrazole-Fused Betulinic Acid Derivatives as Novel Agents for Osteoarthritis Treatment.
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DOI: 10.1021/acs.jmedchem.1c01019
Abstract: A series of pyrazole-fused betulinic acid (BA) derivatives were designed and synthesized by replacing the carboxyl group at C-17 with aliphatic amine, amide, and urea groups. The suppressive effects of the compounds on osteoclast (OC)… read more here.
Keywords: betulinic acid; pyrazole fused; fused betulinic; acid derivatives ... See more keywords