Synthesis and Assessment of Fused β‐Carboline Derivatives as Kappa Opioid Receptor Agonists
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DOI: 10.1002/cmdc.202100029
Abstract: The synthesis of 5‐formyl‐6‐aryl‐6H‐indolo[3,2,1‐de][1,5] naphthyridine‐2‐carboxylates by reaction between 1‐formyl‐9H‐β‐carbolines and cinnamaldehydes in the presence of pyrrolidine in water with microwave irradiation is described. Pharmacophoric modification of the formyl group offered several new fused β‐carboline derivatives,… read more here.
Keywords: opioid receptor; synthesis assessment; carboline derivatives; assessment fused ... See more keywords