Rational Design of Original Fused-Cycle Selective Inhibitors of Tryptophan 2,3-Dioxygenase.
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DOI: 10.1021/acs.jmedchem.1c00323
Abstract: Tryptophan 2,3-dioxygenase (TDO2) is a heme-containing enzyme constitutively expressed at high concentrations in the liver and responsible for l-tryptophan (l-Trp) homeostasis. Expression of TDO2 in cancer cells results in the inhibition of immune-mediated tumor rejection… read more here.
Keywords: fused cycle; design original; rational design; tryptophan dioxygenase ... See more keywords