Furoxans fused with heterocycles as promising donors and precursors for nitric oxide donors (microreview)
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DOI: 10.1007/s10593-017-2135-4
Abstract: This minireview provides the first presentation and analysis of literature data published over recent years on the synthesis and chemical reactivity of 1,2,5-oxadiazole N-oxides (furoxans) fused with other heterocycles (pyridine, pyridazine, pyrimidine, pyrazine, and 1,4-dithiane). read more here.
Keywords: precursors nitric; heterocycles promising; furoxans fused; donors precursors ... See more keywords
Eco-friendly and sustainable synthetic approaches to biologically significant fused N-heterocycles
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DOI: 10.1007/s10593-020-02678-5
Abstract: This review summarizes environmentally benign approaches for the synthesis of fused N-heterocycles since 2011. It is mainly focused on one-pot, multicomponent protocols for generating fused N-heterocyclic moieties with biological significance in atom-efficient manner. Several attractive… read more here.
Keywords: friendly sustainable; approaches biologically; sustainable synthetic; eco friendly ... See more keywords
4-Hydroxy-2-quinolones: syntheses, reactions and fused heterocycles
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DOI: 10.1007/s11030-019-09952-5
Abstract: Abstract The interesting pharmaceutical and biological activities of 4-hydroxy-2-quinolones make them valuable in drug research and development. Hence, many publications have recently dealt with their synthetic analogous and the synthesis of their heteroannelated derivatives. Consequently,… read more here.
Keywords: quinolones syntheses; syntheses reactions; reactions fused; fused heterocycles ... See more keywords
Pd-Catalyzed Domino Imidoylation/Heck/C(sp2)-H Cyclization: Isocyanide Relay Strategy toward Tricyclic-Fused Heterocycles Containing an All-Carbon Quaternary Center.
Sign Up to like & getrecommendations! Published in 2020 at "Organic letters"
DOI: 10.1021/acs.orglett.0c02503
Abstract: A palladium-catalyzed domino process for the quick assembly of tricyclic-fused heterocycles starting from aryl iodides and functionalized isocyanides containing a disubstituted terminal alkene has been developed. The process is triggered by intermolecular isocyanide insertion, followed… read more here.
Keywords: sp2; domino imidoylation; catalyzed domino; fused heterocycles ... See more keywords
Electrocatalytic Intermolecular C(sp3)-H/N-H Coupling of Methyl N-Heteroaromatics with Amines and Amino Acids: Access to Imidazo-Fused N-Heterocycles.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.8b02578
Abstract: An efficient NH4I-mediated intermolecular annulation of methyl N-heteroaromatics with amines/amino acids was developed by virtue of anodic oxidation, providing a variety of functionalized imidazo-fused N-heterocycles with good to excellent yields. The practicality of this protocol… read more here.
Keywords: amino acids; amines amino; fused heterocycles; imidazo fused ... See more keywords
Catalytic Cascade Reaction To Access Cyclopentane-Fused Heterocycles: Expansion of Pd-TMM Cycloaddition.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b01178
Abstract: A palladium-catalyzed reaction of N-aromatic zwitterion and trimethylenemethane that gives fused N-heterocycles via dearomative [3 + 2] cycloaddition and intramolecular cyclization is developed, and a cyclopentane-fused cyclic product is generated. Combining computational and experimental studies,… read more here.
Keywords: catalytic cascade; cycloaddition; cyclopentane fused; reaction ... See more keywords
Sequential C–H and C–C Bond Cleavage: Divergent Constructions of Fused N-Heterocycles via Tunable Cascade
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DOI: 10.1021/acscatal.9b03091
Abstract: Streamlining the generation of diverse highly functionalized molecules from abundant feedstocks holds great synthetic promises and challenges in pharmaceutical and material discovery. Herein, we report a tunable selectivity in multiple cascade reactions for the divergent… read more here.
Keywords: sequential bond; cleavage divergent; bond cleavage; fused heterocycles ... See more keywords