Synthesis of Benzimidazole-Fused Medium-Sized N,S -Heterocycles via Palladium-Catalyzed Cyclizations
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DOI: 10.1002/ejoc.201801686
Abstract: The synthesis of unprecedented benzimidazole-fused thiazocines, thiazonines, and thiazecines having an exocyclic double bond is reported. The process consists in an 8-, 9-, or 10-exo-dig cyclocarbopalladation followed by reduction. The scope and limitations were established… read more here.
Keywords: medium sized; fused medium; sized heterocycles; synthesis benzimidazole ... See more keywords
Pd/P/dba-Promoted cascade annulations to produce fused medium-sized sulfoximine polyheterocycles
Sign Up to like & getrecommendations! Published in 2019 at "Organic chemistry frontiers"
DOI: 10.1039/c9qo00880b
Abstract: The Pd-catalyzed multicomponent reactions of NH-sulfoximine, aryl iodide and norbornadiene (NBD) are reported to chemoselectively produce fused medium-sized sulfoximine polyheterocycles in good to excellent yields. The addition of the dibenzylideneacetone (dba) ligand was found to… read more here.
Keywords: fused medium; sized sulfoximine; medium sized; produce fused ... See more keywords
Computational Evaluation of N-Based Transannular Interactions in Some Model Fused Medium-Sized Heterocyclic Systems and Implications for Drug Design
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28041631
Abstract: As part of a project on fused medium-sized ring systems as potential drugs, we have previously demonstrated the usefulness of Density Functional Theory (DFT) to evaluate amine nitrogen-based transannular interactions across the central 10-membered ring… read more here.
Keywords: medium sized; fused medium; interactions observed; based transannular ... See more keywords