Asymmetric C-H hydroarylation and annulation cascade for the skeletal diversification of dihydrofuran-fused-phthalimides.
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DOI: 10.1039/d5cc03717d
Abstract: We report a Ru(II)-catalyzed enantioselective C(aryl)-H hydroarylation-annulation cascade with isocyanates for the synthesis of structurally diverse dihydrofuran-fused phthalimides. A chiral sulfoximine directing group ensures high enantioselectivity (up to 97 : 3 er). The method exhibits broad substrate… read more here.
Keywords: dihydrofuran fused; annulation cascade; hydroarylation annulation; fused phthalimides ... See more keywords