Efficient synthetic strategies for fused pyrimidine and pyridine derivatives: A review
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.4871
Abstract: Pyrimidine and its derivatives play a paramount role in drug discovery as privileged pharmacophores with considerable chemical and biological significance and its presence in genes. This review aims to assemble a systematic evaluation of synthetic… read more here.
Keywords: chemistry; pyrimidine pyridine; fused pyrimidine; derivatives review ... See more keywords
Ionic liquid promoted synthesis of heterocycle-fused pyrimidine-2,4(1H,3H)-diones utilising CO2
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DOI: 10.1016/j.tetlet.2018.05.043
Abstract: Abstract An efficient ionic liquid system was developed for the preparation of various heterocycle-fused pyrimidine-2, 4(1H,3H)-diones in moderate to excellent yields (52–95%). It was found that [HDBN+][TFE−], a simple and easily prepared ionic liquid, could… read more here.
Keywords: ionic liquid; heterocycle fused; liquid; fused pyrimidine ... See more keywords
Design, Synthesis, and Biological Evaluation of Heterocyclic-Fused Pyrimidine Chemotypes Guided by X-ray Crystal Structure with Potential Antitumor and Anti-multidrug Resistance Efficacy Targeting the Colchicine Binding Site.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c02115
Abstract: Herein, a series of quinazoline and heterocyclic fused pyrimidine analogues were designed and synthesized based on the X-ray co-crystal structure of lead compound 3a, showing efficacious antitumor activities. Two analogues, 15 and 27a, exhibited favorable… read more here.
Keywords: antitumor; colchicine binding; heterocyclic fused; fused pyrimidine ... See more keywords
Non-fused Pyrimidine Derivatives as Potential Pharmacological Entities: A Review.
Sign Up to like & getrecommendations! Published in 2024 at "Current topics in medicinal chemistry"
DOI: 10.2174/0115680266317088240924205745
Abstract: Non-fused pyrimidine scaffold is a significant component for designing new drugs. The review emphasizes the pharmacological importance of non-fused pyrimidine-containing moieties based on the broad spectrum of activities such as antiprotozoal, antibacterial, antimycobacterial, anticancer, anti-inflammatory… read more here.
Keywords: fused pyrimidine; non fused; pyrimidine derivatives; derivatives potential ... See more keywords