General Synthesis and Properties of Bridged, Fused, and Spirocyclic Azacycles via Intramolecular C-H Bond Amination.
Sign Up to like & getrecommendations! Published in 2025 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.5c00468
Abstract: General methods to construct complex azacycles significantly enable the invention of new therapeutics. Herein, we describe a unified strategy to access bridged, fused, and spirocyclic bicyclic azacycles leveraging a Hofmann-Löffler-Freytag (HLF) approach. Our method yields… read more here.
Keywords: fused spirocyclic; bridged fused; synthesis properties; general synthesis ... See more keywords
NBS-induced intramolecular annulation reactions for the divergent synthesis of fused- and spirocyclic indolines.
Sign Up to like & getrecommendations! Published in 2023 at "Chemical communications"
DOI: 10.1039/d3cc01920a
Abstract: An NBS-induced intramolecular annulation of 3-(1H-indol-3-yl)-N-alkoxypropanamide is described. The reactions proceed well and quickly under mild conditions with the help of a base. It was found that C2-substituents on the indole ring in 3-(1H-indol-3-yl)-N-alkoxypropanamide have… read more here.
Keywords: nbs induced; intramolecular annulation; induced intramolecular; divergent synthesis ... See more keywords