SDC1-dependent TGM2 determines radiosensitivity in glioblastoma by coordinating EPG5-mediated fusion of autophagosomes with lysosomes
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2105562
Abstract: ABSTRACT Glioblastoma multiforme (GBM) is the most common brain malignancy insensitive to radiotherapy (RT). Although macroautophagy/autophagy was reported to be a fundamental factor prolonging the survival of tumors under radiotherapeutic stress, the autophagic biomarkers coordinated… read more here.
Keywords: fusion autophagosomes; tgm2; autophagosomes lysosomes; gbm ... See more keywords
Diabetes influences the fusion of autophagosomes with lysosomes in SH-SY5Y cells and induces Aβ deposition and cognitive dysfunction in STZ-induced diabetic rats
Sign Up to like & getrecommendations! Published in 2023 at "Behavioural Brain Research"
DOI: 10.2139/ssrn.4076981
Abstract: Diabetes has been regarded as an independent risk factor for Alzheimer's disease (AD). Our previous study found that diabetes activated autophagy, but lysosome function was impaired. Autophagy-lysosome dysfunction may be involved in Aβ deposition in… read more here.
Keywords: fusion; diabetic rats; fusion autophagosomes; induced diabetic ... See more keywords