Characterization of stage-specific tumor progression in TMPRSS2-ERG (fusion)-driven and non-fusion-driven prostate cancer in GEM models.
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DOI: 10.1002/mc.23413
Abstract: In the present study, we performed a comparative stage-specific pathological and molecular marker evaluation of TMPRSS2-ERG fusion and PTEN loss-driven (TMPRSS2-ERG. Ptenflox/flox ) versus non-fusion-driven prostate tumorigenesis (Hi-Myc) in mice. Anterior, ventral, and dorsolateral prostates… read more here.
Keywords: fusion driven; fusion; erg fusion; stage ... See more keywords
Abstract 3946: VGLL2::NCOA2 structure-function analysis reveals domain requirements for fusion-driven infantile rhabdomyosarcoma
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DOI: 10.1158/1538-7445.am2025-3946
Abstract: Rhabdomyosarcoma (RMS) is the most common pediatric soft-tissue sarcoma and is associated with impaired skeletal muscle differentiation. RMS has significant diagnostic and therapeutic challenges, and the presence of fusion oncogenes contributes to the aggressiveness of… read more here.
Keywords: tdu ad1; fusion; culture; vgll2 ncoa2 ... See more keywords
Abstract 5171: Development of preclinical models of NTRK fusion-driven cancers
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DOI: 10.1158/1538-7445.am2025-5171
Abstract: Oncogenic fusions involving the neurotrophic receptor tyrosine kinase genes, NTRK1, NTRK2, or NTRK3 are detected in both adult and pediatric cancers, including in 1% of a broad range of common cancer types such as lung,… read more here.
Keywords: cancer; fusion; biology; ntrk fusion ... See more keywords