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   Articles with "fusion gene" as a keyword



Characterization of CSF2A fusion gene and its effect on Epstein–Barr virus–positive tumor cells

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recommendations! Published in 2018 at "Journal of Medical Virology"

DOI: 10.1002/jmv.25240

Abstract: We build the latent membrane protein gene latent membrane protein 2A (LMP2A) and the granulocyte‐macrophase colony‐stimulating factor (GM‐CSF) gene fusion gene (CSF2A) and discuss how the CSF2A fusion protein influenced the proliferation and apoptosis of… read more here.

Keywords: fusion gene; gene; tumor cells; csf2a ... See more keywords

A novel fusion gene involving PDGFRB and GCC2 in a chronic eosinophilic leukemia patient harboring t(2;5)(q37;q31)

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recommendations! Published in 2019 at "Molecular Genetics & Genomic Medicine"

DOI: 10.1002/mgg3.591

Abstract: Platelet‐derived growth factor receptor beta (PDGFRB) rearrangement has been reported in a number of patients with chronic eosinophilic leukemia (CEL), B‐acute lymphoblastic leukemia, myeloproliferative neoplasms, and juvenile myelomonocytic leukemia. Here, we report a case of… read more here.

Keywords: gene involving; chronic eosinophilic; eosinophilic leukemia; fusion gene ... See more keywords

Transcriptomic analysis and fusion gene identifications of midbody remnants released from colorectal cancer cells reveals they are molecularly distinct from exosomes and microparticles

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recommendations! Published in 2024 at "PROTEOMICS"

DOI: 10.1002/pmic.202300058

Abstract: Previously, we reported that human primary (SW480) and metastatic (SW620) colorectal (CRC) cells release three classes of membrane‐encapsulated extracellular vesicles (EVs); midbody remnants (MBRs), exosomes (Exos), and microparticles (MPs). We reported that MBRs were molecularly… read more here.

Keywords: cancer; fusion; analysis; fusion gene ... See more keywords

Clinicopathological characteristics and outcome of 31 patients with ETV6-NTRK3 fusion gene confirmed (mammary analogue) secretory carcinoma of salivary glands.

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recommendations! Published in 2018 at "Oral oncology"

DOI: 10.1016/j.oraloncology.2018.04.022

Abstract: OBJECTIVES In 2010, a new subtype of salivary gland cancer (SGC), (mammary analogue) secretory carcinoma (SC), was defined, characterized by the ETV6-NTRK3 fusion gene. As clinical behavior and outcome data of this histological subtype tumor… read more here.

Keywords: fusion gene; etv6 ntrk3; ntrk3 fusion; mammary analogue ... See more keywords

Frequent miRNA-convergent fusion gene events in breast cancer

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recommendations! Published in 2017 at "Nature Communications"

DOI: 10.1038/s41467-017-01176-1

Abstract: Studies of fusion genes have mainly focused on the formation of fusions that result in the production of hybrid proteins or, alternatively, on promoter-switching events that put a gene under the control of aberrant signals.… read more here.

Keywords: breast cancer; fusion gene; fusion genes; fusion ... See more keywords
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Partner independent fusion gene detection by multiplexed CRISPR-Cas9 enrichment and long read nanopore sequencing

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recommendations! Published in 2020 at "Nature Communications"

DOI: 10.1038/s41467-020-16641-7

Abstract: Fusion genes are hallmarks of various cancer types and important determinants for diagnosis, prognosis and treatment. Fusion gene partner choice and breakpoint-position promiscuity restricts diagnostic detection, even for known and recurrent configurations. Here, we develop… read more here.

Keywords: detection; partner; enrichment; fusion gene ... See more keywords

CATCH: high specific transcriptome-focused fusion gene variants discrimination.

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recommendations! Published in 2022 at "Chemical communications"

DOI: 10.1039/d2cc02660k

Abstract: We develop a CRISPR-Cas13a triggered catalytic hairpin assembly (CATCH) approach for accurate and impartial identification of variants by integrating the fusion gene-selected recognition of CRISPR-Cas13a with collateral cleavage-assisted catalytic hairpin assembly amplification. This approach achieved… read more here.

Keywords: fusion; catch high; high specific; specific transcriptome ... See more keywords

PICALM-MLLT10 fusion gene in hematological neoplasms: clinical features, current practices, and prognoses

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recommendations! Published in 2024 at "Hematology"

DOI: 10.1080/16078454.2024.2423324

Abstract: ABSTRACT Introduction: PICALM-MLLT10, formerly CALM-AF10, is a rarely reported fusion gene in hematological malignancies, especially in Asian people. Case presentations: Six patients with PICALM-MALLT10 fusion gene were identified at the First Affiliated Hospital, Zhejiang University… read more here.

Keywords: picalm mllt10; fusion; mllt10 fusion; gene hematological ... See more keywords

ArtiFuse - computational validation of fusion gene detection tools without relying on simulated reads

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recommendations! Published in 2020 at "Bioinformatics"

DOI: 10.1093/bioinformatics/btz613

Abstract: MOTIVATION Gene fusions are an important class of transcriptional variants that can influence cancer development and can be predicted from RNA sequencing (RNA-seq) data by multiple existing tools. However, real world performance of these tools… read more here.

Keywords: fusion gene; gene; rna seq; simulated reads ... See more keywords

Detection of FIP1L1-PDGFRA fusion gene-positive cells in the skin lesion of a patient with hypereosinophilic syndrome.

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recommendations! Published in 2022 at "Clinical and experimental dermatology"

DOI: 10.1093/ced/llac112

Abstract: Hypereosinophilic syndrome (HES) is a heterogeneous group of diseases, characterized by persistent hypereosinophilia and end-organ damage. The FIP1L1-PDGFRA (F/P) fusion gene is found in 3-25% of patients with HES and is an oncogenic driver of… read more here.

Keywords: fusion; pdgfra fusion; hypereosinophilic syndrome; fusion gene ... See more keywords

LGG-54. DETECTION OF THE KIAA1549-BRAF FUSION GENE IN CELLS FORMING MICROVASCULAR PROLIFERATIONS IN PILOCYTIC ASTROCYTOMA

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recommendations! Published in 2020 at "Neuro-Oncology"

DOI: 10.1093/neuonc/noaa222.432

Abstract: Abstract Microvascular proliferation (MVP), an aberrant vascular structure is a histopathological hallmark of glioblastoma multiforme (GBM). Although MVP tends to be associated with high-grade glioma, it has also been detected in WHO grade I pilocytic… read more here.

Keywords: fusion gene; kiaa1549 braf; tumor cells; tumor ... See more keywords