Transcriptome analysis reveals overlap in fusion genes in a phase I clinical cohort of TNBC and HGSOC patients treated with buparlisib and olaparib
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-019-03078-9
Abstract: Purpose Fusion genes can be therapeutically relevant if they result in constitutive activation of oncogenes or repression of tumor suppressors. However, the prevalence and role of fusion genes in female cancers remain largely unexplored. Here,… read more here.
Keywords: fusion genes; hgsoc patients; fusion; tnbc hgsoc ... See more keywords
Advances in chromosomal translocations and fusion genes in sarcomas and potential therapeutic applications.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer treatment reviews"
DOI: 10.1016/j.ctrv.2017.12.001
Abstract: Chromosomal translocations and fusion genes are very common in human cancer especially in subtypes of sarcomas, such as rhabdomyosarcoma, Ewing's sarcoma, synovial sarcoma and liposarcoma. The discovery of novel chromosomal translocations and fusion genes in… read more here.
Keywords: translocations fusion; genes sarcomas; chromosomal translocations; advances chromosomal ... See more keywords
New rapid method to detect BCR-ABL fusion genes with multiplex RT-qPCR in one-tube at a time.
Sign Up to like & getrecommendations! Published in 2018 at "Leukemia research"
DOI: 10.1016/j.leukres.2018.04.001
Abstract: Fast identification of BCR-ABL fusion genes is critical for precise diagnosis, risk stratification and therapy scheme selection in leukemia. More convenient methods are needed for quickly detection of the BCR-ABL fusion genes. Multiplex fluorescent reverse… read more here.
Keywords: fusion genes; bcr; abl fusion; bcr abl ... See more keywords
Frequent miRNA-convergent fusion gene events in breast cancer
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-01176-1
Abstract: Studies of fusion genes have mainly focused on the formation of fusions that result in the production of hybrid proteins or, alternatively, on promoter-switching events that put a gene under the control of aberrant signals.… read more here.
Keywords: breast cancer; fusion gene; fusion genes; fusion ... See more keywords
Clinker: visualizing fusion genes detected in RNA-seq data
Sign Up to like & getrecommendations! Published in 2018 at "GigaScience"
DOI: 10.1093/gigascience/giy079
Abstract: ABSTRACT Background Genomic profiling efforts have revealed a rich diversity of oncogenic fusion genes. While there are many methods for identifying fusion genes from RNA-sequencing (RNA-seq) data, visualizing these transcripts and their supporting reads remains… read more here.
Keywords: clinker; seq data; fusion genes; fusion ... See more keywords
GENE-18. TRANSCRIPTOME-WIDE ANALYSIS USING NANOPORE THIRD GENERATION SEQUENCING IN A RAT GLIOBLASTOMA MODEL: PROOF OF PRINCIPLE
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz175.420
Abstract: The RNA sequencing (RNA-Seq) technique is now routinely used to quantitatively explore genome-wide expression by various research fields including cancer research. The most common RNA-seq methodology produce billions of short-read sequencing in the range of… read more here.
Keywords: fusion genes; expression; third generation; gene ... See more keywords
PATH-56. PYROSEQUENCING METHOD FOR RAPID DETECTION OF KIAA1549-BRAF FUSION GENES IN PEDIATRIC BRAIN TUMORS
Sign Up to like & getrecommendations! Published in 2019 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noz175.651
Abstract: Fusion genes driving tumorigenesis have drawn the attention of oncologists and researchers. Recently, independent genomic researchers have identified a tandem duplication of BRAF at 7q34 that leads to several KIAA1549-BRAF gene exon fusions in the… read more here.
Keywords: braf; braf fusion; fusion genes; fusion ... See more keywords
PAX5 fusion genes in acute lymphoblastic leukemia: A literature review
Sign Up to like & getrecommendations! Published in 2023 at "Medicine"
DOI: 10.1097/md.0000000000033836
Abstract: Acute lymphoblastic leukemia (ALL) is a common cancer affecting children worldwide. The development of ALL is driven by several genes, some of which can be targeted for treatment by inhibiting gene fusions. PAX5 is frequently… read more here.
Keywords: pax5; acute lymphoblastic; pax5 fusion; lymphoblastic leukemia ... See more keywords
Acute myeloid leukemia fusion genes can be found in CD33‐negative cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Laboratory Hematology"
DOI: 10.1111/ijlh.13942
Abstract: Targeted therapies and immunotherapies are emerging strategies for the treatment of leukemia. CD33 is a common and important therapeutic target for cellular immunotherapy or antibody immunotherapy. Drugs on targeting CD33 are also emerging. However, acute… read more here.
Keywords: myeloid leukemia; genes found; leukemia fusion; leukemia ... See more keywords
Phenotypic characterization with somatic genome editing and gene transfer reveals the diverse oncogenicity of ependymoma fusion genes
Sign Up to like & getrecommendations! Published in 2020 at "Acta Neuropathologica Communications"
DOI: 10.1186/s40478-020-01080-8
Abstract: Recurrent RELA and YAP1 fusions are intimately associated with tumorigenesis in supratentorial ependymomas. Chromothripsis and focal copy number alterations involving 11q are hallmarks of these tumors. However, it is unknown whether the chromosomal alterations are… read more here.
Keywords: ependymoma; fusion genes; fusion; gene ... See more keywords
DriverFuse: An R package for analysis of next-generation sequencing datasets to identify cancer driver fusion genes
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0262686
Abstract: We developed the DriverFuse package to integrate orthogonal data types such as Structural Variants (SV) and Copy Number Variations (CNV) to characterize fusion genes in cancer datasets. A fusion gene is reported as a driver… read more here.
Keywords: driver fusion; fusion; analysis; fusion genes ... See more keywords