Efficient treatment and pre-exposure prophylaxis in rhesus macaques by an HIV fusion-inhibitory lipopeptide
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DOI: 10.1016/j.cell.2021.11.032
Abstract: Two HIV fusion-inhibitory lipopeptides (LP-97 and LP-98) were designed with highly potent, long-acting antiviral activity. Monotherapy using a low dose of LP-98 sharply reduced viral loads and maintained long-term viral suppression in 21 SHIVSF162P3-infected rhesus… read more here.
Keywords: pre exposure; rhesus macaques; exposure prophylaxis; fusion inhibitory ... See more keywords
Potency of Fusion-Inhibitory Lipopeptides against SARS-CoV-2 Variants of Concern
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DOI: 10.1128/mbio.01249-22
Abstract: SARS-CoV-2, the causative agent of COVID-19, continues to spread globally, with waves resulting from new variants that evade immunity generated by vaccines and previous strains and escape available monoclonal antibody therapy. Fusion-inhibitory peptides may provide… read more here.
Keywords: inhibitory lipopeptides; monoclonal antibody; sars cov; fusion inhibitory ... See more keywords
Decreased Levels of SARS-CoV-2 Fusion-Inhibitory Antibodies in the Serum of Aged COVID-19 Patients
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DOI: 10.3390/diagnostics12081813
Abstract: Background: The SARS-CoV-2 pandemic was particularly devastating for elderly people, and the underlying mechanisms of the disease are still poorly understood. In this study, we investigated fusion inhibitory antibodies (fiAbs) in elderly and younger COVID-19… read more here.
Keywords: fusion; covid patients; inhibitory antibodies; fusion inhibitory ... See more keywords