DOT1L O-GlcNAcylation promotes its protein stability and MLL-fusion leukemia cell proliferation.
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DOI: 10.1016/j.celrep.2021.109739
Abstract: Histone lysine methylation functions at the interface of the extracellular environment and intracellular gene expression. DOT1L is a versatile histone H3K79 methyltransferase with a prominent role in MLL-fusion leukemia, yet little is known about how… read more here.
Keywords: mll fusion; fusion leukemia; dot1l;